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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2djl FMN Dihydroorotate dehydrogenase (fumarate) 1.3.98.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 1.145
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 1.113
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 1.108
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 1.106
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 1.079
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 1.078
3gye FMNDihydroorotate dehydrogenase (fumarate) / 1.066
4wzh FMNDihydroorotate dehydrogenase (fumarate) / 1.063
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 1.062
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 1.058
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 1.016
3oix FMNDihydroorotate dehydrogenase / 0.932
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.878
4uth FMNXenobiotic reductase / 0.859
4utm FNRXenobiotic reductase / 0.857
4e2d FMNDehydrogenase / 0.851
3l5l FMNXenobiotic reductase / 0.848
1z41 FMNNADPH dehydrogenase / 0.843
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.842
4tmc FMNOld yellow enzyme / 0.841
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.840
5cpm FNRNADH:flavin oxidoreductase / 0.838
1z48 FMNNADPH dehydrogenase / 0.837
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.835
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.831
3hf3 FMNChromate reductase / 0.830
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.829
3l67 FMNXenobiotic reductase / 0.827
4df2 FMNNADPH dehydrogenase / 0.826
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.826
4e2b FMNDehydrogenase / 0.820
4jic FMNGTN Reductase / 0.820
3p74 FMNPentaerythritol tetranitrate reductase / 0.819
4xq6 FMNDihydroorotate dehydrogenase (quinone) / 0.816
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.815
1h63 FMNPentaerythritol tetranitrate reductase / 0.814
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.812
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.812
2abb FMNPentaerythritol tetranitrate reductase / 0.811
1gwj FMNMorphinone reductase / 0.810
3p62 FMNPentaerythritol tetranitrate reductase / 0.810
3atz FMNProstaglandin F2a synthase / 0.807
3n14 FMNXenobiotic reductase / 0.805
3aty FMNProstaglandin F2a synthase / 0.804
1h51 FMNPentaerythritol tetranitrate reductase / 0.803
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.802
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.796
1h50 FMNPentaerythritol tetranitrate reductase / 0.795
3p84 FMNPentaerythritol tetranitrate reductase / 0.793
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.786
1vyr FMNPentaerythritol tetranitrate reductase / 0.781
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.781
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.781
3p8i FMNPentaerythritol tetranitrate reductase / 0.780
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.779
3p8j FMNPentaerythritol tetranitrate reductase / 0.778
4tmb FMNOld yellow enzyme / 0.777
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.774
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.774
3n19 FNRXenobiotic reductase / 0.774
1ep1 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.769
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.767
1z44 FMNNADPH dehydrogenase / 0.767
3p67 FMNPentaerythritol tetranitrate reductase / 0.765
1vhn FMNtRNA-dihydrouridine synthase / 0.760
3gka FMNN-ethylmaleimide reductase / 0.757
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.756
3f03 FMNPentaerythritol tetranitrate reductase / 0.754
1ofe FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.751
4m5p FMNNADPH dehydrogenase / 0.749
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.748
3gr8 FMNNADPH dehydrogenase / 0.747
3tjl FMNNADPH dehydrogenase / 0.744
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.741
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.739
2z6i FMN2-nitropropane dioxygenase / 0.735
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.734
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.734
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.715
4qai FMNNADPH dehydrogenase / 0.714
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.712
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.710
1llw FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.706
4utl FNRXenobiotic reductase / 0.706
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.705
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.695
4cw5 FMNDfnA / 0.694
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.692
2nli FMNLactate oxidase / 0.691
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.691
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.688
1ea0 FMNGlutamate synthase [NADPH] large chain 1.4.1.13 0.686
3p82 FMNPentaerythritol tetranitrate reductase / 0.680
3qe2 FMNNADPH--cytochrome P450 reductase / 0.679
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.676
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.674
2du2 FMNLactate oxidase / 0.671
4rje FNRLactate oxidase / 0.670
2zrx FMNIsopentenyl-diphosphate delta-isomerase / 0.667
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.666
3w77 FMNFMN-dependent NADH-azoreductase / 0.666
3b05 FNRIsopentenyl-diphosphate delta-isomerase / 0.665
1h7w FMNDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.662
4yco FMNtRNA-dihydrouridine(16) synthase / 0.662
2h8x FMNXenA / 0.661
4n65 FMNFMN-dependent NADH-azoreductase 1 / 0.661
2vxa RBFDodecin / 0.659
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.657
3qfr FMNNADPH--cytochrome P450 reductase / 0.657
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.654
2vyx FMNDodecin / 0.651
3n3b FMNProtein NrdI / 0.651