Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2dhf DZF Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2dhf DZFDihydrofolate reductase 1.5.1.3 0.988
4m6k FOLDihydrofolate reductase 1.5.1.3 0.782
1dhf FOLDihydrofolate reductase 1.5.1.3 0.768
4m6l 21VDihydrofolate reductase 1.5.1.3 0.749
1dra MTXDihydrofolate reductase 1.5.1.3 0.739
1drf FOLDihydrofolate reductase 1.5.1.3 0.739
1hfq MOTDihydrofolate reductase 1.5.1.3 0.736
3ghw GHWDihydrofolate reductase 1.5.1.3 0.735
1hfp MOTDihydrofolate reductase 1.5.1.3 0.732
2drc MTXDihydrofolate reductase 1.5.1.3 0.732
3eig MTXDihydrofolate reductase 1.5.1.3 0.729
2fzj DH3Dihydrofolate reductase 1.5.1.3 0.728
4x5g FOLDihydrofolate reductase 1.5.1.3 0.724
1tdr MTXDihydrofolate reductase 1.5.1.3 0.722
1df7 MTXDihydrofolate reductase 1.5.1.3 0.719
4dfr MTXDihydrofolate reductase 1.5.1.3 0.719
1hfr MOTDihydrofolate reductase 1.5.1.3 0.714
4x5h FOLDihydrofolate reductase 1.5.1.3 0.714
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.713
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.713
3dau MTXDihydrofolate reductase 1.5.1.3 0.712
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.711
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.710
3tq9 MTXDihydrofolate reductase / 0.710
1ohj COPDihydrofolate reductase 1.5.1.3 0.706
4x5i FOLDihydrofolate reductase 1.5.1.3 0.705
3och 2MXDihydrofolate reductase 1.5.1.3 0.703
4p66 MTXDihydrofolate reductase / 0.702
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.701
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.700
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.698
3ia4 MTXDihydrofolate reductase / 0.697
4keb FOLDihydrofolate reductase 1.5.1.3 0.697
2zza FOLDihydrofolate reductase / 0.695
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.694
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.694
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.694
1dyh DZFDihydrofolate reductase 1.5.1.3 0.692
1dyi FOLDihydrofolate reductase 1.5.1.3 0.691
3tqb FOLDihydrofolate reductase / 0.691
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.690
2qk8 MTXDihydrofolate reductase / 0.689
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.688
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.687
4kjj FOLDihydrofolate reductase 1.5.1.3 0.686
2d0k FOLDihydrofolate reductase 1.5.1.3 0.683
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.681
1drb MTXDihydrofolate reductase 1.5.1.3 0.680
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.678
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.678
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.677
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.676
4kfj FOLDihydrofolate reductase 1.5.1.3 0.674
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.672
1dls MTXDihydrofolate reductase 1.5.1.3 0.671
2g1m 4HGEgl nine homolog 1 / 0.667
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.666
1dhj MTXDihydrofolate reductase 1.5.1.3 0.665
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.665
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.664
3dat MTXDihydrofolate reductase / 0.661
3drc MTXDihydrofolate reductase 1.5.1.3 0.660
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.659
4p68 MTXDihydrofolate reductase / 0.658
4x5f FOLDihydrofolate reductase 1.5.1.3 0.658
2w3m FOLDihydrofolate reductase 1.5.1.3 0.657
1dhi MTXDihydrofolate reductase 1.5.1.3 0.654
1u70 MTXDihydrofolate reductase 1.5.1.3 0.654
2vp4 DCPDeoxynucleoside kinase / 0.654
1daj MOTDihydrofolate reductase 1.5.1.3 0.653
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.651
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.651