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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2dg9 RAP Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2dg9 RAPPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 1.187
4drj RAPSerine/threonine-protein kinase mTOR 2.7.11.1 1.039
4drj RAPPeptidyl-prolyl cis-trans isomerase FKBP4 5.2.1.8 1.039
2dg4 RAPPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 1.022
2dg3 RAPPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.989
1c9h RAPPeptidyl-prolyl cis-trans isomerase FKBP1B 5.2.1.8 0.970
1nsg RADPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.962
1nsg RADSerine/threonine-protein kinase mTOR 2.7.11.1 0.962
2fap RADPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.962
2fap RADSerine/threonine-protein kinase mTOR 2.7.11.1 0.962
1fkl RAPPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.935
1fkb RAPPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.932
4qt3 RAPPeptidylprolyl isomerase / 0.930
1fap RAPPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.929
1fap RAPSerine/threonine-protein kinase mTOR 2.7.11.1 0.929
4drh RAPSerine/threonine-protein kinase mTOR 2.7.11.1 0.909
4drh RAPPeptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 0.909
4fap ARDPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.876
4fap ARDSerine/threonine-protein kinase mTOR 2.7.11.1 0.876
4drk I63Peptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 0.787
4dh0 MR8Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.777
1fkh SBXPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.757
4drm 0MCPeptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 0.747
1fkg SB3Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.745
4lay I63Peptidyl-prolyl cis-trans isomerase FKBP4 5.2.1.8 0.738
1qpf 858Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.737
3o5r FK5Peptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 0.737
1fkd 818Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.728
4dro 0MDPeptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 0.728
4dz2 FK5Peptidyl-prolyl cis-trans isomerase / 0.728
4odo FK5Peptidyl-prolyl cis-trans isomerase / 0.714
4drn 0MCPeptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 0.713
4drp 0MDPeptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 0.713
1fki SB1Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.704
4dri RAPSerine/threonine-protein kinase mTOR 2.7.11.1 0.694
4dri RAPPeptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 0.694
1bkf FK5Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.687
2fke FK5Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.683
2vn1 FK5Peptidylprolyl isomerase / 0.677
1bl4 AP1Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.674
3fap ARDPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.673
3fap ARDSerine/threonine-protein kinase mTOR 2.7.11.1 0.673
1fkf FK5Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.669
1j4h SUBPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.665
1q6i FK5FKBP-type peptidyl-prolyl cis-trans isomerase FkpA 5.2.1.8 0.665
1qpl 587Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.656
1fkj FK5Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.653