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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c4f GIL Coagulation factor VII 3.4.21.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2c4f GILCoagulation factor VII 3.4.21.21 1.125
1wqv PSMCoagulation factor VII 3.4.21.21 0.758
1wv7 5PICoagulation factor VII 3.4.21.21 0.747
2zi2 24UProthrombin 3.4.21.5 0.727
4bah MELProthrombin 3.4.21.5 0.727
1k22 MELProthrombin 3.4.21.5 0.724
1wtg 3BPCoagulation factor VII 3.4.21.21 0.722
1ghv 120Prothrombin 3.4.21.5 0.712
4ban M6SProthrombin 3.4.21.5 0.708
1owi 426Urokinase-type plasminogen activator 3.4.21.73 0.701
1ypk CCRProthrombin 3.4.21.5 0.697
1vja 7INUrokinase-type plasminogen activator 3.4.21.73 0.693
2zg0 50UProthrombin 3.4.21.5 0.693
2pks G44Prothrombin 3.4.21.5 0.692
2zhq 27UProthrombin 3.4.21.5 0.691
4bam MM9Prothrombin 3.4.21.5 0.690
2znk 31UProthrombin 3.4.21.5 0.686
1riw OSCProthrombin 3.4.21.5 0.685
2zgx 29UProthrombin 3.4.21.5 0.682
4bak M67Prothrombin 3.4.21.5 0.677
2ziq 26UProthrombin 3.4.21.5 0.671
3biu 10UProthrombin 3.4.21.5 0.668
2zp0 PI0Coagulation factor VII 3.4.21.21 0.661
7kme ACE_0BN_CHG_PRRProthrombin 3.4.21.5 0.660
2zfq 45UProthrombin 3.4.21.5 0.659
2zfr 46UProthrombin 3.4.21.5 0.659
4fue 7UPUrokinase-type plasminogen activator 3.4.21.73 0.659
3hat GLY_VAL_ARG_RNGProthrombin 3.4.21.5 0.657
4bao MVFProthrombin 3.4.21.5 0.657
1owk 303Urokinase-type plasminogen activator 3.4.21.73 0.654
2v3h I25Prothrombin 3.4.21.5 0.654
4ax9 N5NProthrombin 3.4.21.5 0.654
3biv 11UProthrombin 3.4.21.5 0.653
1c5n ESIProthrombin 3.4.21.5 0.652
1gj4 132Prothrombin 3.4.21.5 0.650