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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c42 TPP Pyruvate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2c42 TPPPyruvate synthase / 1.201
2c3u 2TPPyruvate synthase / 1.142
2c3o TPPPyruvate synthase / 0.989
2c3y HTLPyruvate synthase / 0.961
2uza HTLPyruvate synthase / 0.940
1kek HTLPyruvate synthase / 0.915
2pda TPPPyruvate synthase / 0.836
2ihu TP9N(2)-(2-carboxyethyl)arginine synthase / 0.759
4k9p TPPBenzoylformate decarboxylase 4.1.1.7 0.752
2w93 TPPPyruvate decarboxylase isozyme 1 / 0.750
2ihv TPPN(2)-(2-carboxyethyl)arginine synthase / 0.736
2ezt TDMPyruvate oxidase 1.2.3.3 0.734
1pvd TPPPyruvate decarboxylase isozyme 1 / 0.730
2vk4 TPPPyruvate decarboxylase 4.1.1.1 0.726
4k9n TZDBenzoylformate decarboxylase 4.1.1.7 0.724
2pan TDPGlyoxylate carboligase 4.1.1.47 0.717
5ej9 TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.715
2q5q TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.713
4gm4 TZDBenzoylformate decarboxylase 4.1.1.7 0.709
1pox TPPPyruvate oxidase 1.2.3.3 0.707
2jla TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.706
5esd TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.706
1pyd TDPPyruvate decarboxylase isozyme 1 / 0.705
2c3p 1TPPyruvate synthase / 0.704
2vk8 TPPPyruvate decarboxylase isozyme 1 / 0.704
2x7j TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.703
4mpr TPPBenzoylformate decarboxylase 4.1.1.7 0.702
4mq5 TPPBenzoylformate decarboxylase 4.1.1.7 0.695
1pow TPPPyruvate oxidase 1.2.3.3 0.692
4juf TPPBenzoylformate decarboxylase 4.1.1.7 0.692
2iht TPPN(2)-(2-carboxyethyl)arginine synthase / 0.689
1ols TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.688
2g28 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.687
3ey9 TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.687
1jsc TPPAcetolactate synthase catalytic subunit, mitochondrial 2.2.1.6 0.686
3fzn D7KBenzoylformate decarboxylase 4.1.1.7 0.686
4cok TPPPyruvate decarboxylase / 0.684
2j9f THV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.682
2j9f THV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial 1.2.4.4 0.682
1po7 TZDBenzoylformate decarboxylase 4.1.1.7 0.681
4juc TPPBenzoylformate decarboxylase 4.1.1.7 0.681
2fwn TDPBenzoylformate decarboxylase 4.1.1.7 0.680
3fsj D7KBenzoylformate decarboxylase 4.1.1.7 0.680
4ju9 TZDBenzoylformate decarboxylase 4.1.1.7 0.680
1upa TPPN(2)-(2-carboxyethyl)arginine synthase / 0.676
2g25 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.676
2v3w TPPBenzoylformate decarboxylase 4.1.1.7 0.676
1y9d TPPPyruvate oxidase 1.2.3.3 0.673
3ahi HTLProbable phosphoketolase / 0.672
3lq2 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.671
4mpp TZDBenzoylformate decarboxylase 4.1.1.7 0.671
4jd5 TZDBenzoylformate decarboxylase 4.1.1.7 0.670
3hwx TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.669
5dgt TZDBenzoylformate decarboxylase 4.1.1.7 0.669
1ovm TPPIndole-3-pyruvate decarboxylase 4.1.1.74 0.668
4qel TZDBenzoylformate decarboxylase 4.1.1.7 0.665
4zp1 TPPPyruvate decarboxylase 4.1.1.1 0.665
3lq4 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.664
3ryh GTPTubulin alpha chain / 0.664
1umc TDP2-oxoisovalerate dehydrogenase subunit alpha 1.2.4.4 0.663
1umc TDP2-oxoisovalerate dehydrogenase subunit beta 1.2.4.4 0.663
4mzx TZDBenzoylformate decarboxylase 4.1.1.7 0.661
1ni4 TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.658
1ni4 TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.658
1mcz TDPBenzoylformate decarboxylase 4.1.1.7 0.655
5c4i TPPOxalate oxidoreductase subunit alpha / 0.651
5c4i TPPOxalate oxidoreductase subunit beta / 0.651
2jlc TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.650
4rwn APC2'-5'-oligoadenylate synthase 1 2.7.7.84 0.650