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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c3u 2TP Pyruvate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2c3u 2TPPyruvate synthase / 1.237
2c42 TPPPyruvate synthase / 1.142
2c3o TPPPyruvate synthase / 0.980
2c3y HTLPyruvate synthase / 0.928
1kek HTLPyruvate synthase / 0.883
2uza HTLPyruvate synthase / 0.867
2pda TPPPyruvate synthase / 0.800
2ezt TDMPyruvate oxidase 1.2.3.3 0.752
2w93 TPPPyruvate decarboxylase isozyme 1 / 0.749
2c3p 1TPPyruvate synthase / 0.748
2ez9 TDKPyruvate oxidase 1.2.3.3 0.747
2ihu TP9N(2)-(2-carboxyethyl)arginine synthase / 0.737
1qpb TPPPyruvate decarboxylase isozyme 1 / 0.728
1jsc TPPAcetolactate synthase catalytic subunit, mitochondrial 2.2.1.6 0.726
2vk8 TPPPyruvate decarboxylase isozyme 1 / 0.721
2ihv TPPN(2)-(2-carboxyethyl)arginine synthase / 0.717
2vk4 TPPPyruvate decarboxylase 4.1.1.1 0.715
4juf TPPBenzoylformate decarboxylase 4.1.1.7 0.715
4k9n TZDBenzoylformate decarboxylase 4.1.1.7 0.713
1pvd TPPPyruvate decarboxylase isozyme 1 / 0.712
4gm4 TZDBenzoylformate decarboxylase 4.1.1.7 0.711
3fsj D7KBenzoylformate decarboxylase 4.1.1.7 0.710
1pox TPPPyruvate oxidase 1.2.3.3 0.709
2j9f THV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.709
2j9f THV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial 1.2.4.4 0.709
1ovm TPPIndole-3-pyruvate decarboxylase 4.1.1.74 0.705
1upc TPPN(2)-(2-carboxyethyl)arginine synthase / 0.705
4zp1 TPPPyruvate decarboxylase 4.1.1.1 0.702
1upa TPPN(2)-(2-carboxyethyl)arginine synthase / 0.701
5ahk TPPAcetolactate synthase II, large subunit / 0.700
1pow TPPPyruvate oxidase 1.2.3.3 0.698
2x7j TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.698
4k9o TPPBenzoylformate decarboxylase 4.1.1.7 0.697
1umc TDP2-oxoisovalerate dehydrogenase subunit alpha 1.2.4.4 0.696
1umc TDP2-oxoisovalerate dehydrogenase subunit beta 1.2.4.4 0.696
1ozh HE3Acetolactate synthase, catabolic 2.2.1.6 0.695
4k9p TPPBenzoylformate decarboxylase 4.1.1.7 0.694
1upb TPPN(2)-(2-carboxyethyl)arginine synthase / 0.686
1y9d TPPPyruvate oxidase 1.2.3.3 0.682
2pan TDPGlyoxylate carboligase 4.1.1.47 0.681
4cok TPPPyruvate decarboxylase / 0.681
4juc TPPBenzoylformate decarboxylase 4.1.1.7 0.678
3hwx TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.677
5c4i TPPOxalate oxidoreductase subunit alpha / 0.672
5c4i TPPOxalate oxidoreductase subunit beta / 0.672
2o1s TDP1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7 0.671
3lq2 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.671
2jla TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.666
4ju9 TZDBenzoylformate decarboxylase 4.1.1.7 0.664
4mpp TZDBenzoylformate decarboxylase 4.1.1.7 0.664
2q5q TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.663
4mpr TPPBenzoylformate decarboxylase 4.1.1.7 0.663
5ej9 TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.663
1ols TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.659
1rp7 TZDPyruvate dehydrogenase E1 component 1.2.4.1 0.658
3ahi HTLProbable phosphoketolase / 0.655
1pyd TDPPyruvate decarboxylase isozyme 1 / 0.654
2qtc TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.653
3exh TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.652
3exh TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.652
4ju8 TZDBenzoylformate decarboxylase 4.1.1.7 0.651
2iht TPPN(2)-(2-carboxyethyl)arginine synthase / 0.650