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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c3o TPP Pyruvate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2c3o TPPPyruvate synthase / 1.193
2c42 TPPPyruvate synthase / 0.989
2c3u 2TPPyruvate synthase / 0.980
2c3y HTLPyruvate synthase / 0.807
2pda TPPPyruvate synthase / 0.774
2uza HTLPyruvate synthase / 0.748
2vk8 TPPPyruvate decarboxylase isozyme 1 / 0.747
2vk4 TPPPyruvate decarboxylase 4.1.1.1 0.745
1kek HTLPyruvate synthase / 0.744
2w93 TPPPyruvate decarboxylase isozyme 1 / 0.739
1pyd TDPPyruvate decarboxylase isozyme 1 / 0.737
2c3p 1TPPyruvate synthase / 0.735
1upc TPPN(2)-(2-carboxyethyl)arginine synthase / 0.728
1pvd TPPPyruvate decarboxylase isozyme 1 / 0.727
4k9n TZDBenzoylformate decarboxylase 4.1.1.7 0.720
2x7j TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.716
2ezt TDMPyruvate oxidase 1.2.3.3 0.709
5ej6 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.709
1upb TPPN(2)-(2-carboxyethyl)arginine synthase / 0.708
4zp1 TPPPyruvate decarboxylase 4.1.1.1 0.707
4cok TPPPyruvate decarboxylase / 0.705
2v3w TPPBenzoylformate decarboxylase 4.1.1.7 0.698
1jsc TPPAcetolactate synthase catalytic subunit, mitochondrial 2.2.1.6 0.694
2j9f THV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.693
2j9f THV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial 1.2.4.4 0.693
3hwx TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.691
2iht TPPN(2)-(2-carboxyethyl)arginine synthase / 0.690
1pow TPPPyruvate oxidase 1.2.3.3 0.686
4k9p TPPBenzoylformate decarboxylase 4.1.1.7 0.684
5ahk TPPAcetolactate synthase II, large subunit / 0.684
4juf TPPBenzoylformate decarboxylase 4.1.1.7 0.682
3fzn D7KBenzoylformate decarboxylase 4.1.1.7 0.679
5esd TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.678
2ihu TP9N(2)-(2-carboxyethyl)arginine synthase / 0.677
3ahi HTLProbable phosphoketolase / 0.676
1pox TPPPyruvate oxidase 1.2.3.3 0.673
1upa TPPN(2)-(2-carboxyethyl)arginine synthase / 0.673
4juc TPPBenzoylformate decarboxylase 4.1.1.7 0.672
4k9o TPPBenzoylformate decarboxylase 4.1.1.7 0.672
4mpr TPPBenzoylformate decarboxylase 4.1.1.7 0.671
1bfd TPPBenzoylformate decarboxylase 4.1.1.7 0.668
2ji6 TPWOxalyl-CoA decarboxylase 4.1.1.8 0.668
1ols TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.665
2jla TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.665
4mpp TZDBenzoylformate decarboxylase 4.1.1.7 0.663
4mzx TZDBenzoylformate decarboxylase 4.1.1.7 0.663
5dgt TZDBenzoylformate decarboxylase 4.1.1.7 0.659
2ji9 TPWOxalyl-CoA decarboxylase 4.1.1.8 0.658
4ju9 TZDBenzoylformate decarboxylase 4.1.1.7 0.658
2ihv TPPN(2)-(2-carboxyethyl)arginine synthase / 0.657
3ahj TPPProbable phosphoketolase / 0.656
3exh TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.654
3exh TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.654
3lq4 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.654
5c4i TPPOxalate oxidoreductase subunit alpha / 0.654
5c4i TPPOxalate oxidoreductase subunit beta / 0.654
2ez9 TDKPyruvate oxidase 1.2.3.3 0.653
1y9d TPPPyruvate oxidase 1.2.3.3 0.652
5ej9 TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.652
1qpb TPPPyruvate decarboxylase isozyme 1 / 0.651