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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c3d COM 2-oxopropyl-CoM reductase, carboxylating 1.8.1.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2c3d COM2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.946
1mo9 KPC2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.716
3q6j KPC2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.706
2vwq NAPGlucose 1-dehydrogenase / 0.704
1toi HCIAspartate aminotransferase 2.6.1.1 0.684
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.668
4a5l NDPThioredoxin reductase / 0.661
3nw4 GTQGentisate 1,2-dioxygenase / 0.654
4dp3 MMVBifunctional dihydrofolate reductase-thymidylate synthase / 0.652
2wba NDPTrypanothione reductase 1.8.1.12 0.651
4ccq NAPThioredoxin reductase / 0.650