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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c31 TZD Oxalyl-CoA decarboxylase 4.1.1.8

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2c31 TZDOxalyl-CoA decarboxylase 4.1.1.8 1.338
2ji9 TPWOxalyl-CoA decarboxylase 4.1.1.8 1.301
2ji7 OXTOxalyl-CoA decarboxylase 4.1.1.8 1.246
2ji6 TPWOxalyl-CoA decarboxylase 4.1.1.8 1.207
2jib TPPOxalyl-CoA decarboxylase 4.1.1.8 1.124
4juf TPPBenzoylformate decarboxylase 4.1.1.7 0.779
4gm0 TZDBenzoylformate decarboxylase 4.1.1.7 0.769
4juc TPPBenzoylformate decarboxylase 4.1.1.7 0.768
4jd5 TZDBenzoylformate decarboxylase 4.1.1.7 0.767
4mpr TPPBenzoylformate decarboxylase 4.1.1.7 0.759
1pvd TPPPyruvate decarboxylase isozyme 1 / 0.743
4k9p TPPBenzoylformate decarboxylase 4.1.1.7 0.737
4mzx TZDBenzoylformate decarboxylase 4.1.1.7 0.734
1umc TDP2-oxoisovalerate dehydrogenase subunit alpha 1.2.4.4 0.727
1umc TDP2-oxoisovalerate dehydrogenase subunit beta 1.2.4.4 0.727
1qpb TPPPyruvate decarboxylase isozyme 1 / 0.723
4k9n TZDBenzoylformate decarboxylase 4.1.1.7 0.723
2ihu TP9N(2)-(2-carboxyethyl)arginine synthase / 0.720
2v3w TPPBenzoylformate decarboxylase 4.1.1.7 0.718
1upa TPPN(2)-(2-carboxyethyl)arginine synthase / 0.717
2iht TPPN(2)-(2-carboxyethyl)arginine synthase / 0.717
3iae D7KBenzaldehyde lyase / 0.716
3fzn D7KBenzoylformate decarboxylase 4.1.1.7 0.710
1upb TPPN(2)-(2-carboxyethyl)arginine synthase / 0.703
1upc TPPN(2)-(2-carboxyethyl)arginine synthase / 0.701
3zhu TD8Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.699
4cok TPPPyruvate decarboxylase / 0.699
2qta TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.698
1pyd TDPPyruvate decarboxylase isozyme 1 / 0.696
1mcz TDPBenzoylformate decarboxylase 4.1.1.7 0.695
5ej9 TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.691
3oe1 TDLPyruvate decarboxylase 4.1.1.1 0.689
5ej4 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.689
3exh TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.688
3exh TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.688
2vk8 TPPPyruvate decarboxylase isozyme 1 / 0.687
4fvq ATPTyrosine-protein kinase JAK2 / 0.686
2ihv TPPN(2)-(2-carboxyethyl)arginine synthase / 0.685
2uz1 TPPBenzaldehyde lyase / 0.681
1pox TPPPyruvate oxidase 1.2.3.3 0.680
5ej7 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.679
2jla TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.677
2pda TPPPyruvate synthase / 0.676
1jsc TPPAcetolactate synthase catalytic subunit, mitochondrial 2.2.1.6 0.675
3exf TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.675
3exf TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.675
3lq2 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.675
1rp7 TZDPyruvate dehydrogenase E1 component 1.2.4.1 0.674
5ej8 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.673
1l8a TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.672
2o1x TDP1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7 0.672
5ej6 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.672
2jlc TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.671
3m0e ATPTranscriptional regulator (NtrC family) / 0.670
3vhx GTPADP-ribosylation factor 6 / 0.670
3zhr TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.669
3zhq TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.668
2w93 TPPPyruvate decarboxylase isozyme 1 / 0.667
4jub TPPBenzoylformate decarboxylase 4.1.1.7 0.667
4gm1 TZDBenzoylformate decarboxylase 4.1.1.7 0.666
3w3z GTPGTP-binding nuclear protein Ran / 0.665
5dac AGSUncharacterized protein / 0.664
2pz8 APCNH(3)-dependent NAD(+) synthetase / 0.662
3dl0 AP5Adenylate kinase / 0.662
3fvq ATPFe(3+) ions import ATP-binding protein FbpC / 0.662
4gm4 TZDBenzoylformate decarboxylase 4.1.1.7 0.662
1ni4 TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.660
1ni4 TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.660
1tkc M6TTransketolase 1 2.2.1.1 0.660
3eya TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.660
5ej5 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.660
5jqg GTPTubulin alpha-1B chain / 0.660
2c3y HTLPyruvate synthase / 0.657
2o1s TDP1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7 0.657
2r8o T5XTransketolase 1 / 0.657
3zht TD9Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.657
3duf R1TPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.656
3duf R1TPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.656
3zhv TDWMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.656
4zp1 TPPPyruvate decarboxylase 4.1.1.1 0.656
2q5o TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.655
3zhs TD6Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.655
4k9o TPPBenzoylformate decarboxylase 4.1.1.7 0.655
1w1w AGSStructural maintenance of chromosomes protein 1 / 0.654
1w88 TDPPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.654
1w88 TDPPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.654
2ag1 TPPBenzaldehyde lyase / 0.654
3dva TPWPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.654
3dva TPWPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.654
2fwn TDPBenzoylformate decarboxylase 4.1.1.7 0.653
1w5a GTPCell division protein FtsZ 1 / 0.651
2q5q TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.651
3hwx TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.650
3m34 TPPTransketolase / 0.650
5ahk TPPAcetolactate synthase II, large subunit / 0.650