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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c0t L3G Tyrosine-protein kinase HCK 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2c0t L3GTyrosine-protein kinase HCK 2.7.10.2 1.114
2c0o L2GTyrosine-protein kinase HCK 2.7.10.2 0.975
2c0i L1GTyrosine-protein kinase HCK 2.7.10.2 0.970
3vs6 VSHTyrosine-protein kinase HCK 2.7.10.2 0.877
3vrz VRZTyrosine-protein kinase HCK 2.7.10.2 0.855
3vs5 VSGTyrosine-protein kinase HCK 2.7.10.2 0.849
3vs4 VSFTyrosine-protein kinase HCK 2.7.10.2 0.828
3vs1 VSATyrosine-protein kinase HCK 2.7.10.2 0.811
3vry B43Tyrosine-protein kinase HCK 2.7.10.2 0.809
3vs0 VS0Tyrosine-protein kinase HCK 2.7.10.2 0.799
3vs3 VSETyrosine-protein kinase HCK 2.7.10.2 0.798
1yol S03Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.756
1qcf PP1Tyrosine-protein kinase HCK 2.7.10.2 0.748
4dgg I76Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.747
1qpe PP2Tyrosine-protein kinase Lck 2.7.10.2 0.721
3vs7 KS1Tyrosine-protein kinase HCK 2.7.10.2 0.716
4k11 0J9Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.713
4d9t 0JGRibosomal protein S6 kinase alpha-3 2.7.11.1 0.706
2ivv PP1Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.699
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.687
4lgg VGGProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.674
3mwu BK3Calmodulin-domain protein kinase 1, putative / 0.671
3qlf PD5Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.667
4yuq KS1Calmodulin-like domain protein kinase / 0.659
3vhe 42QVascular endothelial growth factor receptor 2 2.7.10.1 0.658
3bhm AB3Carbonyl reductase [NADPH] 1 1.1.1.184 0.656
2itz IREEpidermal growth factor receptor 2.7.10.1 0.651