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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c0i L1G Tyrosine-protein kinase HCK 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2c0i L1GTyrosine-protein kinase HCK 2.7.10.2 1.208
2c0t L3GTyrosine-protein kinase HCK 2.7.10.2 0.970
2c0o L2GTyrosine-protein kinase HCK 2.7.10.2 0.967
3vs3 VSETyrosine-protein kinase HCK 2.7.10.2 0.928
3vs4 VSFTyrosine-protein kinase HCK 2.7.10.2 0.864
3vs5 VSGTyrosine-protein kinase HCK 2.7.10.2 0.830
3vrz VRZTyrosine-protein kinase HCK 2.7.10.2 0.826
3vry B43Tyrosine-protein kinase HCK 2.7.10.2 0.819
3vs0 VS0Tyrosine-protein kinase HCK 2.7.10.2 0.796
3vs1 VSATyrosine-protein kinase HCK 2.7.10.2 0.787
1qcf PP1Tyrosine-protein kinase HCK 2.7.10.2 0.775
1yol S03Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.732
3vs7 KS1Tyrosine-protein kinase HCK 2.7.10.2 0.732
4dgg I76Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.715
2ivv PP1Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.714
1qpe PP2Tyrosine-protein kinase Lck 2.7.10.2 0.712
2h8h H8HProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.709
4k11 0J9Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.698
2zoq 5IDMitogen-activated protein kinase 3 2.7.11.24 0.690
3qlf PD5Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.682
5amn DTQProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.677
4lgg VGGProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.673
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.671
4mxo DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.668
4yuq KS1Calmodulin-like domain protein kinase / 0.664
3vhe 42QVascular endothelial growth factor receptor 2 2.7.10.1 0.657
4hjo AQ4Epidermal growth factor receptor 2.7.10.1 0.656
3mvj XFEcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
2itz IREEpidermal growth factor receptor 2.7.10.1 0.654
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.653
3lmg ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 0.650