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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c0c NAP Prostaglandin reductase 3 1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2c0c NAPProstaglandin reductase 3 1 1.391
2zb3 NDPProstaglandin reductase 2 1.3.1.48 0.962
2y05 NAPProstaglandin reductase 1 / 0.932
2vna NAPProstaglandin reductase 2 1.3.1.48 0.887
3jyn NDPQuinone oxidoreductase / 0.858
3qwb NDPProbable quinone oxidoreductase 1.6.5.5 0.827
1qor NDPQuinone oxidoreductase 1 / 0.813
4rvu NDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) / 0.795
4b7x NAPProbable oxidoreductase / 0.745
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.740
2j3k NAPNADPH-dependent oxidoreductase 2-alkenal reductase 1.3.1.74 0.734
2j8z NAPQuinone oxidoreductase PIG3 1 0.717
5dp2 NAPCurF / 0.712
2oby NAPQuinone oxidoreductase PIG3 1 0.702
4k28 NADShikimate dehydrogenase family protein / 0.696
1o8c NDPProbable acrylyl-CoA reductase AcuI 1.3.1.84 0.695
4ej0 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.695
5doz NDPJamJ / 0.687
1iyz NDPProbable quinone oxidoreductase / 0.685
1yqd NAPSinapyl alcohol dehydrogenase / 0.680
4jbi NDPAlcohol dehydrogenase (Zinc) / 0.678
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.677
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.674
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.673
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.672
1nyt NAPShikimate dehydrogenase (NADP(+)) / 0.669
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.665
2c29 NAPDihydroflavonol 4-reductase / 0.664
3ntr NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.664
1guf NDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial 1.3.1.10 0.663
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.663
2wyv NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.661
3ko8 NADNAD-dependent epimerase/dehydratase / 0.660
1gv0 NADMalate dehydrogenase / 0.657
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.657
3q2k NAIProbable oxidoreductase / 0.656
1yqx NAPSinapyl alcohol dehydrogenase / 0.655
4j49 NAIUncharacterized protein / 0.655
4oqy NDP(S)-imine reductase / 0.655
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.654
3keq NADRedox-sensing transcriptional repressor Rex / 0.654
2x0r NADMalate dehydrogenase / 0.653
4b79 NADProbable short-chain dehydrogenase / 0.653
4hwk NAPSepiapterin reductase 1.1.1.153 0.651
4y0k NAPAntE / 0.651
1vl8 NAPOxidoreductase, short chain dehydrogenase/reductase family / 0.650
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.650
5a04 NDPGlucose-fructose oxidoreductase / 0.650