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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2br5 SAH Cephalosporin hydroxylase CmcI

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2br5 SAHCephalosporin hydroxylase CmcI / 1.061
4gf5 SAHCalS11 / 0.743
4xvy SAHMycinamicin III 3''-O-methyltransferase 2.1.1.237 0.742
3tos SAHCalS11 / 0.717
4oa5 SAHO-methyltransferase family protein / 0.709
1skm SAHModification methylase HhaI 2.1.1.37 0.703
3mht SAHModification methylase HhaI 2.1.1.37 0.703
3c3y SAHO-methyltransferase / 0.701
10mh SAHModification methylase HhaI 2.1.1.37 0.698
9mht SAHModification methylase HhaI 2.1.1.37 0.697
2bm9 SAMCephalosporin hydroxylase CmcI / 0.696
3iv6 SAMUncharacterized protein / 0.695
4ymg SAMPutative SAM-dependent O-methyltranferase / 0.694
2np6 NEAModification methylase TaqI 2.1.1.72 0.687
1p1c SAHGuanidinoacetate N-methyltransferase 2.1.1.2 0.685
7mht SAHModification methylase HhaI 2.1.1.37 0.685
3cbg SAHO-methyltransferase / 0.684
3ssm SAHMycinamicin VI 2''-O-methyltransferase / 0.683
4obw SAM2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial / 0.682
4pyo SAHCatechol O-methyltransferase 2.1.1.6 0.681
4x7y SAHMycinamicin III 3''-O-methyltransferase 2.1.1.237 0.680
1i9g SAMtRNA (adenine(58)-N(1))-methyltransferase TrmI / 0.678
1y8q ATPSUMO-activating enzyme subunit 2 6.3.2 0.677
1z3c SA8mRNA cap guanine-N7 methyltransferase 2.1.1.56 0.677
1aqi SAHModification methylase TaqI 2.1.1.72 0.675
2i9k SAHModification methylase HhaI 2.1.1.37 0.675
3tm4 SAMUncharacterized protein / 0.674
5k7w SAHN6-adenosine-methyltransferase 70 kDa subunit / 0.673
2ytz SAHtRNA (guanine(26)-N(2))-dimethyltransferase / 0.671
4ce0 SAHProbable O-methyltransferase / 0.671
2qe6 SAMUncharacterized protein / 0.669
1khh SAHGuanidinoacetate N-methyltransferase 2.1.1.2 0.668
2c7q SAHModification methylase HhaI 2.1.1.37 0.668
2ibt NEAModification methylase TaqI 2.1.1.72 0.668
3vyw SAMUncharacterized protein / 0.668
5il2 SAHN6-adenosine-methyltransferase 70 kDa subunit / 0.668
3duw SAHO-methyltransferase, putative / 0.667
4krh SAMPhosphoethanolamine N-methyltransferase 2 / 0.666
3axt SAMtRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase / 0.664
3orh SAHGuanidinoacetate N-methyltransferase 2.1.1.2 0.664
3ou6 SAMSAM-dependent methyltransferase / 0.664
3qv2 SAH5-cytosine DNA methyltransferase / 0.664
2pwy SAHtRNA (adenine(58)-N(1))-methyltransferase TrmI 2.1.1.220 0.662
3grv ADNProbable ribosomal RNA small subunit methyltransferase A / 0.657
3u81 SAHCatechol O-methyltransferase 2.1.1.6 0.657
4c05 SAHProtein arginine N-methyltransferase 6 / 0.657
3gry SAMProbable ribosomal RNA small subunit methyltransferase A / 0.656
3rfx NADUronate dehydrogenase / 0.654
2hmv ADPKtr system potassium uptake protein A / 0.652
5d4v SAHUncharacterized protein MJ0489 / 0.650