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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2bla CP6 Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2bla CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.851
1j3j CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.765
2bl9 CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.753
3qfx CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.744
2blb CP7Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.738
3qg2 CP6Bifunctional dihydrofolate reductase-thymidylate synthase / 0.736
2blc CP7Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.723
3um5 CP6Bifunctional dihydrofolate reductase-thymidylate synthase / 0.704
4ddr MMVDihydrofolate reductase 1.5.1.3 0.688
3qgt CP6Bifunctional dihydrofolate reductase-thymidylate synthase / 0.679
1m7a MQUDihydrofolate reductase 1.5.1.3 0.677
3um6 1CYBifunctional dihydrofolate reductase-thymidylate synthase / 0.677
1m78 CLZDihydrofolate reductase 1.5.1.3 0.667
1aoe GW3Dihydrofolate reductase 1.5.1.3 0.666
1ia2 TQ4Dihydrofolate reductase 1.5.1.3 0.662
3cse N22Uncharacterized protein / 0.659
1ia3 TQ5Dihydrofolate reductase 1.5.1.3 0.657
4kne 1CYDihydrofolate reductase 1.5.1.3 0.655
3qlr QLRDihydrofolate reductase 1.5.1.3 0.651