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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2bkz SBC Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2bkz SBCCyclin-dependent kinase 2 2.7.11.22 0.945
2wip P49Cyclin-dependent kinase 2 2.7.11.22 0.703
1vyw 292Cyclin-dependent kinase 2 2.7.11.22 0.674
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.667
4f64 0S8Fibroblast growth factor receptor 1 / 0.662
4cfn JYMCyclin-dependent kinase 2 2.7.11.22 0.660
2vn9 GVDCalcium/calmodulin-dependent protein kinase type II subunit delta 2.7.11.17 0.656
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.655
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.652
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.651
5ax3 5IDMitogen-activated protein kinase 1 2.7.11.24 0.650