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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2bi8 FAD UDP-galactopyranose mutase 5.4.99.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 1.457
1wam FADUDP-galactopyranose mutase 5.4.99.9 1.401
2bi7 FADUDP-galactopyranose mutase 5.4.99.9 1.276
3int FDAUDP-galactopyranose mutase 5.4.99.9 1.218
3kyb FADUDP-galactopyranose mutase 5.4.99.9 1.188
1i8t FADUDP-galactopyranose mutase 5.4.99.9 1.028
4mo2 FDAUDP-galactopyranose mutase / 0.962
3he3 FADUDP-galactopyranose mutase / 0.953
4mo2 FADUDP-galactopyranose mutase / 0.893
1rsg FADPolyamine oxidase FMS1 / 0.868
2yg7 FADPutrescine oxidase / 0.864
3hdy FADUDP-galactopyranose mutase / 0.851
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.849
4u8k FDAUDP-galactopyranose mutase / 0.837
4u8i FDAUDP-galactopyranose mutase / 0.835
3uth FDAUDP-galactopyranose mutase / 0.827
4u8n FDAUDP-galactopyranose mutase / 0.825
4gde FDAUDP-galactopyranose mutase / 0.821
4dsh FDAUncharacterized protein / 0.814
4i58 FADCyclohexylamine Oxidase / 0.813
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.812
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.811
4wx1 FDAUDP-galactopyranose mutase / 0.804
3utf FDAUDP-galactopyranose mutase / 0.803
3utg FDAUDP-galactopyranose mutase / 0.803
2jb1 FADL-amino acid oxidase / 0.802
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.801
4xbf FADLysine-specific histone demethylase 1A 1 0.801
3kve FADL-amino-acid oxidase / 0.798
4u8m FDAUDP-galactopyranose mutase / 0.797
4u8o FDAUDP-galactopyranose mutase / 0.792
4u8p FDAUDP-galactopyranose mutase / 0.786
4u8j FDAUDP-galactopyranose mutase / 0.785
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.784
2yg6 FADPutrescine oxidase / 0.784
4guu FA9Lysine-specific histone demethylase 1B 1 0.784
2qa1 FADPgaE / 0.782
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.779
2yg4 FADPutrescine oxidase / 0.778
4u8l FDAUDP-galactopyranose mutase / 0.778
3qj4 FADRenalase / 0.767
3cty FADProbable thioredoxin reductase / 0.761
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.760
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.760
2e1m FADL-glutamate oxidase / 0.759
5br7 FADUDP-galactopyranose mutase / 0.757
2gv8 FADThiol-specific monooxygenase 1.14.13 0.753
4rpj FADUDP-galactopyranose mutase 5.4.99.9 0.752
2c4c FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.744
2xvf FADPutative flavin-containing monooxygenase / 0.741
3cnt FADPolyamine oxidase FMS1 / 0.741
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.740
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.740
2yvj FADFerredoxin reductase / 0.737
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.737
4rsl FADFructosyl peptide oxidase / 0.737
2hko FADLysine-specific histone demethylase 1A 1 0.736
2jae FADL-amino acid oxidase / 0.736
3bi5 FADPolyamine oxidase FMS1 / 0.736
2uxx FAJLysine-specific histone demethylase 1A 1 0.735
2jb2 FADL-amino acid oxidase / 0.733
4icy FADPgaE / 0.731
3cnd FADPolyamine oxidase FMS1 / 0.730
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.728
4ap3 FADSteroid monooxygenase / 0.728
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.727
2yg5 FADPutrescine oxidase / 0.727
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.725
4fwf FADLysine-specific histone demethylase 1B 1 0.725
4gut FADLysine-specific histone demethylase 1B 1 0.725
3bi2 FADPolyamine oxidase FMS1 / 0.723
3ict FADCoenzyme A disulfide reductase / 0.722
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.719
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.718
3cn8 FADPolyamine oxidase FMS1 / 0.717
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.716
3ukk FADUDP-galactopyranose mutase / 0.716
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.715
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.715
5l3d FADLysine-specific histone demethylase 1A 1 0.715
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.714
2dw4 FADLysine-specific histone demethylase 1A 1 0.714
4tm1 FDAKtzI / 0.714
1b8s FADCholesterol oxidase 1.1.3.6 0.713
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.712
4jq9 FADDihydrolipoyl dehydrogenase / 0.712
4fwj FADLysine-specific histone demethylase 1B 1 0.710
3hdy FDAUDP-galactopyranose mutase / 0.708
3atq FDAConserved Archaeal protein / 0.707
3gwf FADCyclohexanone monooxygenase / 0.707
3ukf FDAUDP-galactopyranose mutase / 0.707
1f8s FADL-amino-acid oxidase 1.4.3.2 0.706
4j33 FADKynurenine 3-monooxygenase / 0.706
1npx FADNADH peroxidase 1.11.1.1 0.705
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.704
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.703
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.703
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.702
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.702
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.701
2eq8 FADDihydrolipoyl dehydrogenase / 0.701
1f8w FADNADH peroxidase 1.11.1.1 0.700
2gvc FADThiol-specific monooxygenase 1.14.13 0.700
3kpf FADPolyamine oxidase 1.5.3.14 0.700
4g9k FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.700
1cbo FADCholesterol oxidase 1.1.3.6 0.699
1nhs FADNADH peroxidase 1.11.1.1 0.699
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.697
4j2w FADKynurenine 3-monooxygenase / 0.697
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.696
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.696
3zdn FADMonoamine oxidase N 1.4.3.4 0.696
4yry FADGlutamate synthase, beta subunit / 0.696
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.695
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.695
3vqr FADPutative oxidoreductase / 0.695
1f8r FADL-amino-acid oxidase 1.4.3.2 0.694
2q0l FADThioredoxin reductase 1.8.1.9 0.694
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.694
2iid FADL-amino-acid oxidase 1.4.3.2 0.693
3nn6 FB06-hydroxy-L-nicotine oxidase / 0.693
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.693
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.692
1yy5 FADPolyamine oxidase FMS1 / 0.692
4b1b FADThioredoxin reductase 1.8.1.9 0.691
2eq9 FADDihydrolipoyl dehydrogenase / 0.690
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.690
2gmj FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.690
3we0 FADLysine 2-monooxygenase / 0.690
2xve FADPutative flavin-containing monooxygenase / 0.689
4j36 FADKynurenine 3-monooxygenase / 0.689
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.689
1kif FADD-amino-acid oxidase 1.4.3.3 0.688
1p1h NADInositol-3-phosphate synthase 5.5.1.4 0.688
3ute FADUDP-galactopyranose mutase / 0.688
4em4 FADCoenzyme A disulfide reductase / 0.688
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.688
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.687
3ukl FADUDP-galactopyranose mutase / 0.686
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.685
3ukk FDAUDP-galactopyranose mutase / 0.685
2bac FADPutative aminooxidase / 0.684
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.683
3m13 FADMonomeric sarcosine oxidase 1.5.3.1 0.683
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.683
2wba FADTrypanothione reductase 1.8.1.12 0.682
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.682
3icr FADCoenzyme A disulfide reductase / 0.682
4bjz FADProbable salicylate monooxygenase / 0.682
4gcm FADThioredoxin reductase 1.8.1.9 0.682
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.682
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.681
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.681
2eq6 FADDihydrolipoyl dehydrogenase / 0.681
4bk2 FADProbable salicylate monooxygenase / 0.681
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.680
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.679
1h83 FADPolyamine oxidase 1.5.3.14 0.679
1mxt FAECholesterol oxidase 1.1.3.6 0.679
1n1p FADCholesterol oxidase 1.1.3.6 0.679
1n4w FADCholesterol oxidase 1.1.3.6 0.679
1nhr FADNADH peroxidase 1.11.1.1 0.679
3alm FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.679
3lov FADProtoporphyrinogen oxidase / 0.679
2eq7 FADDihydrolipoyl dehydrogenase / 0.678
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.678
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.678
4bk3 FADProbable salicylate monooxygenase / 0.678
2w0h FADTrypanothione reductase / 0.677
4b68 FADL-ornithine N(5)-monooxygenase / 0.676
4k2x FADPolyketide oxygenase/hydroxylase / 0.676
2zbw FADFerredoxin--NADP reductase / 0.675
3atr FDAConserved Archaeal protein / 0.675
4ysh FADGlycine oxidase / 0.675
1xpq FADPolyamine oxidase FMS1 / 0.674
2cvj FADThioredoxin reductase related protein / 0.673
3kkj FADRenalase / 0.673
3s5w FADL-ornithine N(5)-monooxygenase / 0.673
2y48 FADLysine-specific histone demethylase 1A 1 0.672
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.672
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.672
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.671
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.671
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.671
3r9u FADThioredoxin reductase / 0.671
3up4 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.671
4aos FADSteroid monooxygenase / 0.671
1pdh FASp-hydroxybenzoate hydroxylase / 0.670
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.669
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.669
1ger FADGlutathione reductase 1.8.1.7 0.668
1geu FADGlutathione reductase 1.8.1.7 0.668
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.668
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.668
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.668
4g74 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.668
4h4w FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.668
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.667
3cgd FADCoenzyme A disulfide reductase / 0.667
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.667
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.667
4cnk FADL-amino acid oxidase / 0.667
4tm3 FADKtzI / 0.667
4ynt FDAGlucose oxidase, putative / 0.667
1ges FADGlutathione reductase 1.8.1.7 0.666
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.666
1ogi FADFerredoxin--NADP reductase 1.18.1.2 0.666
2h94 FADLysine-specific histone demethylase 1A 1 0.666
3lsi FADPyranose 2-oxidase / 0.666
4j31 FADKynurenine 3-monooxygenase / 0.666
4rek FADCholesterol oxidase 1.1.3.6 0.666
4xxg FADCholesterol oxidase 1.1.3.6 0.666
1f3p FADFerredoxin reductase / 0.665
1reo FADL-amino-acid oxidase 1.4.3.2 0.665
4z26 FADPutative GMC-type oxidoreductase R135 1 0.665
2xvh FADPutative flavin-containing monooxygenase / 0.664
1k0l FADp-hydroxybenzoate hydroxylase / 0.663
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.663
3cgc FADCoenzyme A disulfide reductase / 0.663
3ept FDAPutative FAD-monooxygenase / 0.663
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.663
1ogj FADFerredoxin--NADP reductase 1.18.1.2 0.662
1tdn FADL-amino-acid oxidase 1.4.3.2 0.662
2xdo FADTetX family tetracycline inactivation enzyme / 0.662
3cge FADCoenzyme A disulfide reductase / 0.662
4gus FADLysine-specific histone demethylase 1B 1 0.662
1n4u FAECholesterol oxidase 1.1.3.6 0.661
2npx FADNADH peroxidase 1.11.1.1 0.661
3alj FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.661
4iv8 SAMPhosphoethanolamine N-methyltransferase,putative / 0.661
4opc FDAConserved Archaeal protein / 0.661
4rph FADUDP-galactopyranose mutase 5.4.99.9 0.661
2bab FADPutative aminooxidase / 0.660
3lad FADDihydrolipoyl dehydrogenase / 0.660
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.660
1h81 FADPolyamine oxidase 1.5.3.14 0.659
2ba9 FADPutative aminooxidase / 0.659
3gyj FADCholesterol oxidase 1.1.3.6 0.659
4tm4 FDAKtzI / 0.659
1bjk FADFerredoxin--NADP reductase 1.18.1.2 0.658
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.658
4pyo SAHCatechol O-methyltransferase 2.1.1.6 0.658
5j60 FADThioredoxin reductase / 0.658
2gqw FADFerredoxin reductase / 0.657
2zrx FMNIsopentenyl-diphosphate delta-isomerase / 0.657
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.657
4k5r FADOxygenase / 0.657
4kx6 FADFumarate reductase flavoprotein subunit 1.3.5.4 0.657
5buk FADFADH2-dependent halogenase / 0.657
3k4n FADPyranose 2-oxidase / 0.656
3rp8 FADFAD-dependent urate hydroxylase / 0.656
4tlz FADKtzI / 0.656
1d7l RFLp-hydroxybenzoate hydroxylase / 0.655
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.655
1gxf FADTrypanothione reductase 1.8.1.12 0.655
1nhq FADNADH peroxidase 1.11.1.1 0.655
1q1w FADPutidaredoxin reductase 1.18.1.5 0.655
1ylu FMNOxygen-insensitive NAD(P)H nitroreductase / 0.655
3b03 VNRIsopentenyl-diphosphate delta-isomerase / 0.655
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.655
3t2k FADSulfide-quinone reductase / 0.655
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.655
1bzl FADTrypanothione reductase 1.8.1.12 0.654
1fec FADTrypanothione reductase 1.8.1.12 0.654
1get FADGlutathione reductase 1.8.1.7 0.654
2b9x FADPutative aminooxidase / 0.654
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.654
2wow FADTrypanothione reductase / 0.654
3t37 FADPyridoxine 4-oxidase / 0.654
4em3 FADCoenzyme A disulfide reductase / 0.654
2oa1 FADFlavin-dependent tryptophan halogenase RebH 1.14.19.9 0.653
2rgo FADAlpha-Glycerophosphate Oxidase / 0.653
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.653
2x8h FADThioredoxin glutathione reductase / 0.653
4emw FADCoenzyme A disulfide reductase / 0.653
4eqx FADCoenzyme A disulfide reductase / 0.653
4fwe FADLysine-specific histone demethylase 1B 1 0.653
4mih FADPyranose 2-oxidase 1.1.3.10 0.653
1feb FADTrypanothione reductase 1.8.1.12 0.652
1n4v FADCholesterol oxidase 1.1.3.6 0.652
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.652
3bnk FMNFlavoredoxin / 0.652
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.652
4qi5 FADCellobiose dehydrogenase / 0.652
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.652
1ryi FADGlycine oxidase 1.4.3.19 0.651
2pt6 S4MSpermidine synthase / 0.651
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.651
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.651
4opi FDAConserved Archaeal protein / 0.651
1yki FMNOxygen-insensitive NAD(P)H nitroreductase / 0.650
2r0c FADPutative FAD-monooxygenase / 0.650
2xlp FADPutative flavin-containing monooxygenase / 0.650
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.650
4xwr FADCholesterol oxidase 1.1.3.6 0.650