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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2b52 D42 Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2b52 D42Cyclin-dependent kinase 2 2.7.11.22 0.895
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.744
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.744
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4e5l DBHPolymerase acidic protein / 0.744
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.744
2b55 D31Cyclin-dependent kinase 2 2.7.11.22 0.738
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.726
1ke6 LS2Cyclin-dependent kinase 2 2.7.11.22 0.714
1ke7 LS3Cyclin-dependent kinase 2 2.7.11.22 0.701
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.700
3ql8 X01Cyclin-dependent kinase 2 2.7.11.22 0.687
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.685
4fkp LS5Cyclin-dependent kinase 2 2.7.11.22 0.682
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.682
3ezr EZRCyclin-dependent kinase 2 2.7.11.22 0.676
1ke8 LS4Cyclin-dependent kinase 2 2.7.11.22 0.672
1ke5 LS1Cyclin-dependent kinase 2 2.7.11.22 0.668
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 0.666
4fkq 42KCyclin-dependent kinase 2 2.7.11.22 0.666
4fkg 4CKCyclin-dependent kinase 2 2.7.11.22 0.665
3qzf X66Cyclin-dependent kinase 2 2.7.11.22 0.663
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1p0e PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1ulb GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3py0 SU9Cyclin-dependent kinase 2 2.7.11.22 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4h7z GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4fsm HK1Serine/threonine-protein kinase Chk1 2.7.11.1 0.659
4fsq HK3Serine/threonine-protein kinase Chk1 2.7.11.1 0.659
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.657
3g0f B49Mast/stem cell growth factor receptor Kit 2.7.10.1 0.656
3lfn A27Cyclin-dependent kinase 2 2.7.11.22 0.656
1pxp CK8Cyclin-dependent kinase 2 2.7.11.22 0.654
1ke9 LS5Cyclin-dependent kinase 2 2.7.11.22 0.653
3qzg X67Cyclin-dependent kinase 2 2.7.11.22 0.652
3qqh X0ACyclin-dependent kinase 2 2.7.11.22 0.651
4fkv 61KCyclin-dependent kinase 2 2.7.11.22 0.651
1fvt 106Cyclin-dependent kinase 2 2.7.11.22 0.650