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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2b4y APR NAD-dependent protein deacylase sirtuin-5, mitochondrial

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2b4y APRNAD-dependent protein deacylase sirtuin-5, mitochondrial / 1.146
1m2g APRNAD-dependent protein deacylase 1 / 0.944
1m2h APRNAD-dependent protein deacylase 1 / 0.897
5d7o AR6NAD-dependent protein deacetylase sirtuin-2 3.5.1 0.883
1m2k APRNAD-dependent protein deacylase 1 / 0.865
2h59 3ODNAD-dependent protein deacetylase / 0.857
5d7p AR6NAD-dependent protein deacetylase sirtuin-2 3.5.1 0.825
4bvb AR6NAD-dependent protein deacetylase sirtuin-3, mitochondrial 3.5.1 0.824
5d7q AR6NAD-dependent protein deacetylase sirtuin-2 3.5.1 0.820
2h59 APRNAD-dependent protein deacetylase / 0.819
4bvh AR6NAD-dependent protein deacetylase sirtuin-3, mitochondrial 3.5.1 0.792
1yc2 APRNAD-dependent protein deacylase 2 / 0.783
1m2j APRNAD-dependent protein deacylase 1 / 0.775
3zg6 APRNAD-dependent protein deacetylase sirtuin-6 3.5.1 0.762
4g1c CNANAD-dependent protein deacylase sirtuin-5, mitochondrial / 0.733
4zzj CNANAD-dependent protein deacetylase sirtuin-1 3.5.1 0.731
1s7g APRNAD-dependent protein deacylase 2 / 0.711
2od7 A1RNAD-dependent protein deacetylase HST2 3.5.1 0.702
3d4b DZDNAD-dependent protein deacetylase / 0.693
4iao APRNAD-dependent histone deacetylase SIR2 3.5.1 0.691
3nn6 FB06-hydroxy-L-nicotine oxidase / 0.689
1y9d FADPyruvate oxidase 1.2.3.3 0.673
2qqf A1RNAD-dependent protein deacetylase HST2 3.5.1 0.662
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.656
1d4o NAPNAD(P) transhydrogenase, mitochondrial / 0.651