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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2aqk NAI Enoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2aqk NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.204
2aqi NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.161
2aq8 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.144
2aqh NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.138
4dre NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.091
4dti NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.058
4trn NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.052
3oey NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.027
2nv6 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.025
4dqu NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.014
3oew NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.010
3of2 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.002
2ieb ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.001
2ie0 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.971
4bqp NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.971
2idz ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.947
4bii NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.909
4zju NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.906
5koi NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.900
2ntv P1HEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.889
2b37 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.887
2h9i EADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.883
4m87 NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.882
4bgi NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.876
4oxy NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.858
1eny NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.856
2b35 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.856
5cpb NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.843
2ntj P1HEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.837
1mg5 NAIAlcohol dehydrogenase 1.1.1.1 0.800
1vrw NAIEnoyl-ACP reductase / 0.799
4qxm NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.780
2b36 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.779
2wyv NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.775
3uic NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.774
3ijr NADOxidoreductase, short chain dehydrogenase/reductase family / 0.754
3r3s NADPutative oxidoreductase / 0.744
4fj0 NAP17beta-hydroxysteroid dehydrogenase / 0.744
4k6f NAPPutative Acetoacetyl-CoA reductase / 0.740
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.737
1b16 NAQAlcohol dehydrogenase 1.1.1.1 0.734
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.732
5idw NAPShort-chain dehydrogenase/reductase SDR / 0.731
2pr2 DG1Enoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.729
3rj9 NADAlcohol dehydrogenase 1.1.1.1 0.729
1enz NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.725
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.725
2gdz NAD15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.1.1.141 0.724
3rj5 NADAlcohol dehydrogenase 1.1.1.1 0.723
2yw9 NAPEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.722
1p44 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.721
4yag NAIC alpha-dehydrogenase / 0.711
1zid ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.707
3bhi NAPCarbonyl reductase [NADPH] 1 1.1.1.184 0.705
4b79 NADProbable short-chain dehydrogenase / 0.705
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.704
4yai NAIC alpha-dehydrogenase / 0.704
5jyd NADShort chain dehydrogenase / 0.704
1b15 NAEAlcohol dehydrogenase 1.1.1.1 0.703
2ztu NADD(-)-3-hydroxybutyrate dehydrogenase / 0.701
1rkx NADCDP-D-glucose-4,6-dehydratase / 0.700
4kwh NAPReductase homolog / 0.700
4o1m NADEnoyl-acyl carrier reductase / 0.700
1h5q NAPNADP-dependent mannitol dehydrogenase 1.1.1.138 0.698
4qec NAPElxO / 0.698
3s55 NADPutative short-chain dehydrogenase/reductase / 0.693
1b2l NDCAlcohol dehydrogenase 1.1.1.1 0.691
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.691
2dte NAIGlucose 1-dehydrogenase related protein / 0.689
2ag5 NAD3-hydroxybutyrate dehydrogenase type 2 / 0.688
2ztv NADD(-)-3-hydroxybutyrate dehydrogenase / 0.687
4nbu NAI3-oxoacyl-(Acyl-carrier-protein) reductase / 0.686
2yut NAPPutative short-chain oxidoreductase / 0.684
1oaa NAPSepiapterin reductase 1.1.1.153 0.682
1xg5 NAPDehydrogenase/reductase SDR family member 11 / 0.682
4is3 NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 1.17.98.1 0.681
4qed NAPElxO / 0.681
1u7t TDT3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.680
2nq8 ZIDEnoyl-ACP reductase / 0.680
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.679
3ko8 NADNAD-dependent epimerase/dehydratase / 0.679
3sx2 NADUncharacterized protein / 0.678
4bms NAPAlclohol dehydrogenase/short-chain dehydrogenase / 0.678
1vl8 NAPOxidoreductase, short chain dehydrogenase/reductase family / 0.677
3ai3 NDPNADPH-sorbose reductase / 0.677
3zu2 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.677
2c59 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.676
2p5y NADUDP-glucose 4-epimerase / 0.676
2wsb NADGalactitol dehydrogenase / 0.675
3vdq NAD3-hydroxybutyrate dehydrogenase / 0.675
2q2v NADBeta-D-hydroxybutyrate dehydrogenase / 0.674
3ai2 NDPNADPH-sorbose reductase / 0.673
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.673
1enp NADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic 1.3.1.9 0.672
1sby NADAlcohol dehydrogenase 1.1.1.1 0.672
3ak4 NADNADH-dependent quinuclidinone reductase / 0.672
3aut NAIGlucose 1-dehydrogenase 4 1.1.1.47 0.672
4o0l NDPNADPH-dependent 3-quinuclidinone reductase / 0.672
3gy0 NAPNAD(P)-dependent oxidoreductase / 0.671
4fj1 NAP17beta-hydroxysteroid dehydrogenase / 0.671
3tsc NADUncharacterized protein / 0.670
4fj2 NAP17beta-hydroxysteroid dehydrogenase / 0.670
4fn4 NADShort chain dehydrogenase / 0.670
1pr9 NAPL-xylulose reductase 1.1.1.10 0.669
1sny NAPLD36273p / 0.669
3mje NDPAmphB / 0.668
3sju NDPKeto reductase / 0.667
1orr NADCDP-paratose 2-epimerase / 0.666
3uxy NADShort-chain dehydrogenase/reductase SDR / 0.666
3wds NADNADH-dependent quinuclidinone reductase / 0.666
1w73 NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.665
3o26 NDPSalutaridine reductase / 0.664
4bmv NAPShort-chain dehydrogenase / 0.663
4hxy NDPPlm1 / 0.663
4wec NADShort chain dehydrogenase / 0.663
5js6 NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.663
3l77 NJPShort-chain alcohol dehydrogenase / 0.662
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.662
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.660
3rue NADUDP-N-acetylglucosamine 4-epimerase / 0.660
1gco NADGlucose 1-dehydrogenase 1.1.1.47 0.659
1gee NADGlucose 1-dehydrogenase 1.1.1.47 0.659
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.657
2c54 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.656
3qrw NDPPutative ketoacyl reductase 1.3.1 0.656
1ae1 NAPTropinone reductase 1 / 0.653
5lc1 NADL-threonine 3-dehydrogenase / 0.653
1b14 NADAlcohol dehydrogenase 1.1.1.1 0.652
1bvr NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.652
1e5q NDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming] 1.5.1.10 0.652
2o23 NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.652
3k31 NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.652
3ru7 NADUDP-N-acetylglucosamine 4-epimerase / 0.652
4eue NAITrans-2-enoyl-CoA reductase [NADH] / 0.652
4b8z NAPGDP-L-fucose synthase 1.1.1.271 0.650
5jsf NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.650