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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2apg FAD Flavin-dependent tryptophan halogenase PrnA 1.14.19.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2apg FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 1.440
2ar8 FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 1.306
2aqj FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 1.226
4z44 FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 1.203
2wes FADTryptophan 5-halogenase / 0.987
2jkc FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.947
2ard FDAFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.925
4z43 FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.892
2wet FADTryptophan 5-halogenase / 0.851
2oa1 FADFlavin-dependent tryptophan halogenase RebH 1.14.19.9 0.809
2oal FADFlavin-dependent tryptophan halogenase RebH 1.14.19.9 0.780
5hy5 FADTryptophan 6-halogenase / 0.756
4gde FDAUDP-galactopyranose mutase / 0.741
1c0l FADD-amino-acid oxidase 1.4.3.3 0.725
3m13 FADMonomeric sarcosine oxidase 1.5.3.1 0.721
3cuk FADD-amino-acid oxidase 1.4.3.3 0.715
4u8o FDAUDP-galactopyranose mutase / 0.713
3gsi FADDimethylglycine oxidase 1.5.3.10 0.712
5i39 FADL-amino acid deaminase / 0.708
3cnt FADPolyamine oxidase FMS1 / 0.703
3uth FDAUDP-galactopyranose mutase / 0.703
4jnq FDAThioredoxin reductase / 0.702
1rsg FADPolyamine oxidase FMS1 / 0.701
3pvc FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.701
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.700
2yg4 FADPutrescine oxidase / 0.700
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.697
3ukf FDAUDP-galactopyranose mutase / 0.697
4opi FDAConserved Archaeal protein / 0.697
3znp FADD-amino-acid oxidase 1.4.3.3 0.696
4wx1 FDAUDP-galactopyranose mutase / 0.696
3f8r NAPNADH oxidase/thioredoxin reductase / 0.695
2yg7 FADPutrescine oxidase / 0.693
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.691
1i0s FMNFerric-chelate reductase (NAD(P)H) / 0.689
2iid FADL-amino-acid oxidase 1.4.3.2 0.687
4u8i FDAUDP-galactopyranose mutase / 0.687
3gwf FADCyclohexanone monooxygenase / 0.685
3kve FADL-amino-acid oxidase / 0.684
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.684
4yau FADNADPH--cytochrome P450 reductase / 0.683
4ynt FDAGlucose oxidase, putative / 0.683
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.682
4u8m FDAUDP-galactopyranose mutase / 0.682
1ep3 FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit / 0.681
1q1w FADPutidaredoxin reductase 1.18.1.5 0.681
3ka7 FADPutative oxidoreductase / 0.681
4u8k FDAUDP-galactopyranose mutase / 0.681
4u8n FDAUDP-galactopyranose mutase / 0.681
3dme FADPutative conserved exported protein / 0.680
3f8p NADNADH oxidase/thioredoxin reductase / 0.679
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.679
4u8p FDAUDP-galactopyranose mutase / 0.679
3utg FDAUDP-galactopyranose mutase / 0.678
4opg FDAConserved Archaeal protein / 0.678
3atr FDAConserved Archaeal protein / 0.676
3gmb FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.676
5j60 FADThioredoxin reductase / 0.676
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.675
1c0k FADD-amino-acid oxidase 1.4.3.3 0.674
2tpr FADTrypanothione reductase 1.8.1.12 0.673
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.673
3qvr FADGlucose oxidase 1.1.3.4 0.673
3sgl FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.673
3we0 FADLysine 2-monooxygenase / 0.672
3k7t FAD6-hydroxy-L-nicotine oxidase / 0.671
3ute FADUDP-galactopyranose mutase / 0.671
4u8j FDAUDP-galactopyranose mutase / 0.671
2du8 FADD-amino-acid oxidase 1.4.3.3 0.669
3nix FADFlavoprotein/dehydrogenase / 0.669
4opu FDAConserved Archaeal protein / 0.669
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.668
3bi2 FADPolyamine oxidase FMS1 / 0.668
3gag FMNPutative NADH dehydrogenase NAD(P)H nitroreductase / 0.668
3k30 ADPHistamine dehydrogenase / 0.668
4opl FDAConserved Archaeal protein / 0.668
4y9u FADNADPH--cytochrome P450 reductase / 0.668
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.666
4gdp FADPolyamine oxidase FMS1 / 0.666
3ad9 FADSubunit beta of sarcosine oxidase / 0.665
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.664
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.664
4ech FADPolyamine oxidase FMS1 / 0.664
4opt FDAConserved Archaeal protein / 0.664
1ng3 FADGlycine oxidase 1.4.3.19 0.663
2rgh FADAlpha-Glycerophosphate Oxidase / 0.663
3rha FDAPutrescine oxidase / 0.663
1f8s FADL-amino-acid oxidase 1.4.3.2 0.662
2whd FADThioredoxin reductase / 0.662
2wp5 FADTrypanothione reductase / 0.662
3cty FADProbable thioredoxin reductase / 0.662
1q1r FADPutidaredoxin reductase 1.18.1.5 0.661
2iyi FMNAppA, antirepressor of ppsR, sensor of blue light / 0.661
5djt FMNNPH1-2 / 0.661
3cgd FADCoenzyme A disulfide reductase / 0.660
3ukl FADUDP-galactopyranose mutase / 0.660
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.659
1zk7 FADMercuric reductase 1.16.1.1 0.659
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.658
2rab FADGlutathione amide reductase / 0.658
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.658
4ytn FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.658
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.658
4jy2 FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.657
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.656
1tdk FADL-amino-acid oxidase 1.4.3.2 0.656
2qcu FADAerobic glycerol-3-phosphate dehydrogenase 1.1.5.3 0.656
4c3x FAD3-ketosteroid dehydrogenase / 0.656
1npx FADNADH peroxidase 1.11.1.1 0.655
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.655
3lsh FADPyranose 2-oxidase / 0.655
1d7y FADFerredoxin reductase / 0.653
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.653
3fmw FADOxygenase / 0.653
4j36 FADKynurenine 3-monooxygenase / 0.653
4nwz FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.653
1gpe FADGlucose oxidase 1.1.3.4 0.652
1yqz FADCoenzyme A disulfide reductase / 0.652
2gr3 FADFerredoxin reductase / 0.652
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.652
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.652
3if9 FADGlycine oxidase 1.4.3.19 0.652
3mj4 FADUDP-galactopyranose mutase / 0.652
3ept FDAPutative FAD-monooxygenase / 0.651
1geu FADGlutathione reductase 1.8.1.7 0.650
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.650
2e1m FADL-glutamate oxidase / 0.650
3lsi FADPyranose 2-oxidase / 0.650
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.650
4i58 FADCyclohexylamine Oxidase / 0.650
4y9r FADNADPH--cytochrome P450 reductase / 0.650