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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ama DHT Androgen receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ama DHTAndrogen receptor / 1.181
1t79 DHTAndrogen receptor / 1.134
4oey DHTAndrogen receptor / 1.133
4oea DHTAndrogen receptor / 1.131
1t73 DHTAndrogen receptor / 1.130
1t74 DHTAndrogen receptor / 1.130
2pio DHTAndrogen receptor / 1.130
2pit DHTAndrogen receptor / 1.125
1t65 DHTAndrogen receptor / 1.115
1t7r DHTAndrogen receptor / 1.112
4oez DHTAndrogen receptor / 1.112
2pip DHTAndrogen receptor / 1.111
1t5z DHTAndrogen receptor / 1.077
4oed DHTAndrogen receptor / 1.074
4ofr DHTAndrogen receptor / 1.071
2piq DHTAndrogen receptor / 1.053
2piw DHTAndrogen receptor / 1.053
2pkl DHTAndrogen receptor / 1.047
2ylp TESAndrogen receptor / 1.040
1t76 DHTAndrogen receptor / 1.030
2z4j DHTAndrogen receptor / 1.030
1t7m DHTAndrogen receptor / 1.022
2q7i TESAndrogen receptor / 1.022
2pix DHTAndrogen receptor / 1.018
2q7k TESAndrogen receptor / 1.007
4hlw TESAndrogen receptor / 0.967
1t7f DHTAndrogen receptor / 0.953
2pnu ENMAndrogen receptor / 0.950
1xj7 DHTAndrogen receptor / 0.914
1t7t DHTAndrogen receptor / 0.885
2ao6 R18Androgen receptor / 0.858
2piu DHTAndrogen receptor / 0.848
2piv DHTAndrogen receptor / 0.840
1t63 DHTAndrogen receptor / 0.822
1xow R18Androgen receptor / 0.821
4ofu DHTAndrogen receptor / 0.816
2am9 TESAndrogen receptor / 0.782
1gs4 ZK5Androgen receptor / 0.776
2pir DHTAndrogen receptor / 0.766
4e5l DBHPolymerase acidic protein / 0.763
2q7j TESAndrogen receptor / 0.762
1xq3 R18Androgen receptor / 0.749
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
2ylq TESAndrogen receptor / 0.738
2q7l TESAndrogen receptor / 0.734
2ylo TESAndrogen receptor / 0.733
4k7a DHTAndrogen receptor / 0.718
2yhd TESAndrogen receptor / 0.702
1qyw 5SDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.701
1xu7 CPSCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.693
1lri CLRBeta-elicitin cryptogein / 0.691
1g50 ESTEstrogen receptor / 0.689
4qe6 JN3Bile acid receptor / 0.685
2d09 FLVBiflaviolin synthase CYP158A2 / 0.682
2qpy DHTAndrogen receptor / 0.682
1lhn AONSex hormone-binding globulin / 0.681
3uzx AOX3-oxo-5-beta-steroid 4-dehydrogenase / 0.681
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.681
3uzx AOM3-oxo-5-beta-steroid 4-dehydrogenase / 0.679
3nhx ASDSteroid Delta-isomerase 5.3.3.1 0.677
1lho AOMSex hormone-binding globulin / 0.672
3f3y 4OABile salt sulfotransferase 2.8.2.14 0.672
2abi 1CAMineralocorticoid receptor / 0.664
3cot STR3-oxo-5-beta-steroid 4-dehydrogenase / 0.663
1jtv TESEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.661
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.661
4e5f 0N7Polymerase acidic protein / 0.660
3cmf PDN3-oxo-5-beta-steroid 4-dehydrogenase / 0.653
1sqn NDRProgesterone receptor / 0.651
1yhs STUSerine/threonine-protein kinase pim-1 2.7.11.1 0.650