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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ahc VNL Chorismate pyruvate-lyase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ahc VNLChorismate pyruvate-lyase / 0.996
3bgz VX3Serine/threonine-protein kinase pim-1 2.7.11.1 0.694
2xke WI2Serine/threonine-protein kinase Nek2 2.7.11.1 0.687
4bi0 Z0WDual specificity protein kinase TTK 2.7.12.1 0.671
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.670
4iwn GEKCarboxy-S-adenosyl-L-methionine synthase / 0.665
1hfq MOTDihydrofolate reductase 1.5.1.3 0.664
3mpi GRAGlutaryl-CoA dehydrogenase 1.3.99.32 0.661
3rm7 19ZCyclin-dependent kinase 2 2.7.11.22 0.660
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.659
1u5a BIKL-lactate dehydrogenase 1.1.1.27 0.659
3vp6 HLDGlutamate decarboxylase 1 4.1.1.15 0.659
2j41 5GPGuanylate kinase / 0.658
3dh8 B4NUncharacterized protein PA1000 / 0.656
4x5h FOLDihydrofolate reductase 1.5.1.3 0.656
2d0k FOLDihydrofolate reductase 1.5.1.3 0.655
3bqr 4RBDeath-associated protein kinase 3 / 0.655
3mzb BHRNickel-binding periplasmic protein / 0.655
4b6l 9ZPSerine/threonine-protein kinase PLK3 2.7.11.21 0.654
2f2u M77Rho-associated protein kinase 2 2.7.11.1 0.653
2fum MIXSerine/threonine-protein kinase PknB 2.7.11.1 0.653
2jb4 A14Isopenicillin N synthase 1.21.3.1 0.652
2isj FMN5,6-dimethylbenzimidazole synthase 1.13.11.79 0.650
4fsz HK8Serine/threonine-protein kinase Chk1 2.7.11.1 0.650