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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ag0 TPP Benzaldehyde lyase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ag0 TPPBenzaldehyde lyase / 1.217
2uz1 TPPBenzaldehyde lyase / 1.036
3d7k D7KBenzaldehyde lyase / 0.985
3iae D7KBenzaldehyde lyase / 0.983
2ag1 TPPBenzaldehyde lyase / 0.973
5ahk TPPAcetolactate synthase II, large subunit / 0.825
4qpz TPPBenzaldehyde lyase / 0.808
2q5q TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.804
5eso TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.800
1jsc TPPAcetolactate synthase catalytic subunit, mitochondrial 2.2.1.6 0.786
2q5o TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.770
3ey9 TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.769
2iea TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.766
2ihu TP9N(2)-(2-carboxyethyl)arginine synthase / 0.763
4k9p TPPBenzoylformate decarboxylase 4.1.1.7 0.760
2g25 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.757
4jub TPPBenzoylformate decarboxylase 4.1.1.7 0.756
5esd TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.749
1umc TDP2-oxoisovalerate dehydrogenase subunit alpha 1.2.4.4 0.748
1umc TDP2-oxoisovalerate dehydrogenase subunit beta 1.2.4.4 0.748
4k9n TZDBenzoylformate decarboxylase 4.1.1.7 0.747
1kek HTLPyruvate synthase / 0.745
1mcz TDPBenzoylformate decarboxylase 4.1.1.7 0.745
2x7j TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.745
3iaf TPPBenzaldehyde lyase / 0.745
2jlc TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.743
5eja TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.740
1y9d TPPPyruvate oxidase 1.2.3.3 0.739
3dva TPWPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.739
3dva TPWPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.739
4k9o TPPBenzoylformate decarboxylase 4.1.1.7 0.739
5ej9 TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.736
3oe1 TDLPyruvate decarboxylase 4.1.1.1 0.735
4cok TPPPyruvate decarboxylase / 0.732
4mpr TPPBenzoylformate decarboxylase 4.1.1.7 0.730
2uza HTLPyruvate synthase / 0.728
1po7 TZDBenzoylformate decarboxylase 4.1.1.7 0.726
3exf TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.726
3exf TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.726
3exh TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.725
3exh TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.725
3fsj D7KBenzoylformate decarboxylase 4.1.1.7 0.721
5ej6 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.720
1pox TPPPyruvate oxidase 1.2.3.3 0.719
2g28 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.718
2vk8 TPPPyruvate decarboxylase isozyme 1 / 0.718
2qta TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.717
4ju8 TZDBenzoylformate decarboxylase 4.1.1.7 0.716
1pow TPPPyruvate oxidase 1.2.3.3 0.715
5c4i TPPOxalate oxidoreductase subunit alpha / 0.715
5c4i TPPOxalate oxidoreductase subunit beta / 0.715
2vk4 TPPPyruvate decarboxylase 4.1.1.1 0.714
3dv0 TPWPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.714
3dv0 TPWPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.714
1ovm TPPIndole-3-pyruvate decarboxylase 4.1.1.74 0.712
4jd5 TZDBenzoylformate decarboxylase 4.1.1.7 0.711
3lq2 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.709
2ez9 TDKPyruvate oxidase 1.2.3.3 0.708
4mq5 TPPBenzoylformate decarboxylase 4.1.1.7 0.708
1upa TPPN(2)-(2-carboxyethyl)arginine synthase / 0.706
4mpp TZDBenzoylformate decarboxylase 4.1.1.7 0.705
1pyd TDPPyruvate decarboxylase isozyme 1 / 0.704
4juf TPPBenzoylformate decarboxylase 4.1.1.7 0.704
2v3w TPPBenzoylformate decarboxylase 4.1.1.7 0.703
3zhs TD6Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.701
4juc TPPBenzoylformate decarboxylase 4.1.1.7 0.700
2w93 TPPPyruvate decarboxylase isozyme 1 / 0.699
4gm0 TZDBenzoylformate decarboxylase 4.1.1.7 0.699
1ni4 TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.697
1ni4 TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.697
2iht TPPN(2)-(2-carboxyethyl)arginine synthase / 0.696
4zp1 TPPPyruvate decarboxylase 4.1.1.1 0.694
3fzn D7KBenzoylformate decarboxylase 4.1.1.7 0.689
1v11 TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.687
2ihv TPPN(2)-(2-carboxyethyl)arginine synthase / 0.687
1pvd TPPPyruvate decarboxylase isozyme 1 / 0.685
4qel TZDBenzoylformate decarboxylase 4.1.1.7 0.685
1bfd TPPBenzoylformate decarboxylase 4.1.1.7 0.674
2ezt TDMPyruvate oxidase 1.2.3.3 0.672
2jla TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.671
2o1s TDP1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7 0.670
1itz TPPTransketolase, chloroplastic 2.2.1.1 0.659
4gg1 TZDBenzoylformate decarboxylase 4.1.1.7 0.658
4gm4 TZDBenzoylformate decarboxylase 4.1.1.7 0.658
1w88 TDPPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.655
1w88 TDPPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.655
3ahj TPPProbable phosphoketolase / 0.655
2pan TDPGlyoxylate carboligase 4.1.1.47 0.654
3duf R1TPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.654
3duf R1TPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.654
3ahi HTLProbable phosphoketolase / 0.651
5ej8 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.651
2qtc TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.650