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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2aax PDN Mineralocorticoid receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2aax PDNMineralocorticoid receptor / 1.110
2aa2 AS4Mineralocorticoid receptor / 0.980
2aa7 1CAMineralocorticoid receptor / 0.973
1y9r 1CAMineralocorticoid receptor / 0.930
2abi 1CAMineralocorticoid receptor / 0.922
2ab2 SNLMineralocorticoid receptor / 0.882
3vhu SNLMineralocorticoid receptor / 0.822
4udc DEXGlucocorticoid receptor / 0.793
4a2j AS0Progesterone receptor / 0.765
1gs4 ZK5Androgen receptor / 0.755
2oax SNLMineralocorticoid receptor / 0.744
2w8y 486Progesterone receptor / 0.738
2piv DHTAndrogen receptor / 0.733
2pkl DHTAndrogen receptor / 0.733
2q7k TESAndrogen receptor / 0.725
2w8y NDRProgesterone receptor / 0.714
2ovh AS0Progesterone receptor / 0.712
1t7r DHTAndrogen receptor / 0.701
3d90 NOGProgesterone receptor / 0.700
1sqn NDRProgesterone receptor / 0.696
2aa6 STRMineralocorticoid receptor / 0.691
1p8d CO1Oxysterols receptor LXR-beta / 0.680
4oed DHTAndrogen receptor / 0.680
4dvq 1CACytochrome P450 11B2, mitochondrial 1.14.15.4 0.677
4hlw TESAndrogen receptor / 0.677
4k7a DHTAndrogen receptor / 0.675
3cas ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.674
2qpy DHTAndrogen receptor / 0.672
4oey DHTAndrogen receptor / 0.672
2a3i C0RMineralocorticoid receptor / 0.671
2ovm AS0Progesterone receptor / 0.671
4p6w MOFGlucocorticoid receptor / 0.671
3mne DEXGlucocorticoid receptor / 0.669
1xf0 ASDAldo-keto reductase family 1 member C3 / 0.667
1f5f DHTSex hormone-binding globulin / 0.665
2qd4 CHDFerrochelatase, mitochondrial 4.99.1.1 0.663
2yhd TESAndrogen receptor / 0.662
2ylo TESAndrogen receptor / 0.662
3w5r LOAVitamin D3 receptor / 0.661
1m2z DEXGlucocorticoid receptor / 0.660
2jn3 JN3Fatty acid-binding protein, liver / 0.658
1t79 DHTAndrogen receptor / 0.657
2piq DHTAndrogen receptor / 0.657
2piu DHTAndrogen receptor / 0.656
1ya3 STRMineralocorticoid receptor / 0.655
2pit DHTAndrogen receptor / 0.655
3cot STR3-oxo-5-beta-steroid 4-dehydrogenase / 0.654
3oll ESTEstrogen receptor beta / 0.653
1t7f DHTAndrogen receptor / 0.652
4oea DHTAndrogen receptor / 0.652
2piw DHTAndrogen receptor / 0.650