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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2a94 AP0 L-lactate dehydrogenase 1.1.1.27

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2a94 AP0L-lactate dehydrogenase 1.1.1.27 1.134
1t2d NADL-lactate dehydrogenase 1.1.1.27 1.062
1pzh NADLactate dehydrogenase / 1.006
1sow NADL-lactate dehydrogenase 1.1.1.27 1.000
1pzg A3DLactate dehydrogenase / 0.977
1pzf A3DLactate dehydrogenase / 0.956
2aa3 AP0L-lactate dehydrogenase / 0.934
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.918
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.918
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.901
2a92 NAIL-lactate dehydrogenase / 0.901
4ros APRMalate dehydrogenase / 0.877
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.870
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.868
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.828
5a1t NAIL-lactate dehydrogenase / 0.816
1gv0 NADMalate dehydrogenase / 0.794
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.792
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.782
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.781
1uxk NADMalate dehydrogenase / 0.776
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.774
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.771
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.767
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.766
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.766
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.766
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.763
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.762
1ib6 NADMalate dehydrogenase / 0.760
1bmd NADMalate dehydrogenase / 0.759
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.758
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.757
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.757
4i1i NADMalate dehydrogenase / 0.754
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.753
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.753
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.753
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.752
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.750
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.750
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.750
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.750
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.749
1bdm NAXMalate dehydrogenase / 0.748
1wze NADMalate dehydrogenase / 0.745
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.744
2x0i NAIMalate dehydrogenase / 0.741
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.741
1b8v NADMalate dehydrogenase / 0.740
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.739
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.739
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.733
1uxj NADMalate dehydrogenase / 0.732
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.731
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.730
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.728
1ie3 NADMalate dehydrogenase / 0.726
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.722
1o6z NADMalate dehydrogenase / 0.720
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.718
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.717
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.712
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.711
2yy7 NADL-threonine dehydrogenase / 0.709
1b8u NADMalate dehydrogenase / 0.707
4j43 NADUncharacterized protein / 0.707
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.707
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.705
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.704
4k28 NADShikimate dehydrogenase family protein / 0.704
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.704
4j4b NAIUncharacterized protein / 0.702
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.700
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.699
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.699
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.698
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.697
1f8f NADBenzyl alcohol dehydrogenase / 0.696
3wfj NAD2-dehydropantoate 2-reductase / 0.696
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.695
2dvm NAD439aa long hypothetical malate oxidoreductase (NAD) [malic enzyme] / 0.694
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.694
1y7t NDPMalate dehydrogenase / 0.693
1c1d NAIPhenylalanine dehydrogenase / 0.692
1guy NADMalate dehydrogenase / 0.691
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.691
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.689
1up7 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.689
1wzi NDPMalate dehydrogenase / 0.688
1ur5 NADMalate dehydrogenase / 0.686
1u7h NADPutative ornithine cyclodeaminase / 0.685
4b7x NAPProbable oxidoreductase / 0.684
4cpd NADAlcohol dehydrogenase / 0.684
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.683
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.681
2dc1 NADProbable L-aspartate dehydrogenase / 0.681
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.680
1dxy NADD-2-hydroxyisocaproate dehydrogenase 1.1.1 0.678
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.678
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.678
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.678
3lu1 NADUDP-N-acetylglucosamine 4-epimerase / 0.677
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.676
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.676
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.676
3gvi ADPMalate dehydrogenase / 0.674
2wdz NADGalactitol dehydrogenase / 0.673
3tqh NDPQuinone oxidoreductase / 0.671
2o4c NADErythronate-4-phosphate dehydrogenase / 0.670
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.669
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.668
2vhx NADAlanine dehydrogenase 1.4.1.1 0.668
4c4o NADSADH / 0.668
1h2h NADL-aspartate dehydrogenase 1.4.1.21 0.667
4b4o NDPEpimerase family protein SDR39U1 / 0.666
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.665
3abi NADUncharacterized protein / 0.664
3h3f NAIL-lactate dehydrogenase A chain 1.1.1.27 0.664
3kb6 NADD-lactate dehydrogenase / 0.664
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.664
4plp NADHomospermidine synthase 2.5.1.44 0.663
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.661
1i3l NADUDP-glucose 4-epimerase / 0.661
1nqa NADGlyceraldehyde-3-phosphate dehydrogenase / 0.661
4xq9 NADHomospermidine synthase 2.5.1.44 0.661
2cvq NDPMalate dehydrogenase / 0.660
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.659
3jv7 NADSecondary alcohol dehydrogenase / 0.659
1npt NADGlyceraldehyde-3-phosphate dehydrogenase / 0.658
2hjr APRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase / 0.658
3gvh NADMalate dehydrogenase / 0.658
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.658
3qvw NADMyo-inositol-1-phosphate synthase (Ino1) / 0.658
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.657
3wmx NADNAD dependent epimerase/dehydratase / 0.657
2x0r NADMalate dehydrogenase / 0.655
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.655
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.655
4kug NAD3-hydroxybutyryl-CoA dehydrogenase / 0.655
2p9g NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.654
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.654
4ej0 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.654
4xcv NDPProbable hydroxyacid dehydrogenase protein / 0.653
2bgm NAJSecoisolariciresinol dehydrogenase 1.1.1.331 0.651
2q1s NAIPutative nucleotide sugar epimerase/ dehydratase / 0.651
4cr8 NADN-acylmannosamine 1-dehydrogenase 1.1.1.233 0.651
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.650
1rwb NADGlucose 1-dehydrogenase 1.1.1.47 0.650
2p5y NADUDP-glucose 4-epimerase / 0.650
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.650
4rqu NADAlcohol dehydrogenase class-P / 0.650