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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2a41 ATP Actin, alpha skeletal muscle

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2a41 ATPActin, alpha skeletal muscle / 1.181
4b1v ATPActin, alpha skeletal muscle / 1.060
4k41 ATPActin, alpha skeletal muscle / 1.030
1qz5 ATPActin, alpha skeletal muscle / 1.029
3mn6 ATPActin-5C / 1.028
1kxp ATPActin, alpha skeletal muscle / 1.025
3a5o ATPMajor actin / 1.021
1wua ATPActin, alpha skeletal muscle / 1.016
1nlv ATPMajor actin / 1.012
3chw ATPMajor actin / 0.995
2q36 ATPActin, alpha skeletal muscle / 0.993
1t44 ATPActin, alpha skeletal muscle / 0.992
2v51 ATPActin, alpha skeletal muscle / 0.991
4cbx ATPActin-2 / 0.990
3m1f ATPActin, alpha skeletal muscle / 0.984
3mn9 ATPActin-5C / 0.983
4pl8 ATPActin, alpha skeletal muscle / 0.980
2q97 ATPActin, alpha skeletal muscle / 0.979
3w3d ATPActin, gamma-enteric smooth muscle / 0.979
3m6g ATPActin, alpha skeletal muscle / 0.968
4pki ATPActin, alpha skeletal muscle / 0.967
1dej ATPMajor actin / 0.966
4pkg ATPActin, alpha skeletal muscle / 0.963
1s22 ATPActin, alpha skeletal muscle / 0.947
3eks ATPActin-5C / 0.947
2p9k ATPActin-related protein 2 / 0.935
3daw ATPActin, alpha skeletal muscle / 0.931
3mn7 ATPActin-5C / 0.928
1atn ATPActin, alpha skeletal muscle / 0.924
3eku ATPActin-5C / 0.924
1eqy ATPActin, alpha skeletal muscle / 0.916
2oan ATPActin, cytoplasmic 1 / 0.909
3el2 ATPActin-5C / 0.899
1c0f ATPMajor actin / 0.894
3ffk ATPActin, alpha skeletal muscle / 0.893
5ce3 ATPActin / 0.872
1ijj ATPActin, alpha skeletal muscle / 0.863
4pkh ADPActin, alpha skeletal muscle / 0.861
3a5m ATPMajor actin / 0.858
1mdu ATPActin, alpha skeletal muscle / 0.855
4jhd ANPActin-5C / 0.851
3tu5 ATPActin, alpha skeletal muscle / 0.847
1lot ATPActin, alpha skeletal muscle / 0.843
1rgi ATPActin, alpha skeletal muscle / 0.831
4m63 ATPActin-5C / 0.830
4k42 ADPActin, alpha skeletal muscle / 0.829
4ci6 ATPActin / 0.823
4ehu ANP2-hydroxyisocaproyl-CoA dehydratase activator / 0.820
1nmd ATPMajor actin / 0.814
1nm1 ATPMajor actin / 0.801
1h1v ATPActin, alpha skeletal muscle / 0.791
1yxq ATPActin, alpha skeletal muscle / 0.786
1rfq ATPActin, alpha skeletal muscle / 0.753
3wt0 ATPCell division protein FtsA / 0.748
3wqt ANPCell division protein FtsA / 0.742
4k43 ADPActin, alpha skeletal muscle / 0.717
3ule ATPActin-related protein 2 / 0.711
4bri UNPEctonucleoside triphosphate diphosphohydrolase I / 0.706
4brd ANPEctonucleoside triphosphate diphosphohydrolase I / 0.692
4brg GNPEctonucleoside triphosphate diphosphohydrolase I / 0.690
4yj2 GTPTubulin alpha-1B chain / 0.687
2zgz GNPPlasmid segregation protein ParM / 0.685
3zcb ATPAdenosine monophosphate-protein transferase VbhT 2.7.7.n1 0.684
2fsn ADPArchaeal actin homolog / 0.681
5itz GTPTubulin alpha-1B chain / 0.676
1rqj IPEFarnesyl diphosphate synthase 2.5.1.10 0.671
5c03 AGSNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.671
3wqu ATPCell division protein FtsA / 0.669
1ngh ATPHeat shock cognate 71 kDa protein / 0.668
2x60 GTPMannose-1-phosphate guanylyltransferase / 0.666
3u4l ATPActin, cytoplasmic 1 / 0.666
3ryh GTPTubulin alpha chain / 0.665
5bsm ATP4-coumarate--CoA ligase 2 6.2.1.12 0.664
5cns DATRibonucleoside-diphosphate reductase 1 subunit alpha 1.17.4.1 0.662
4tv9 GTPTubulin alpha-1B chain / 0.661
2q16 ITTdITP/XTP pyrophosphatase / 0.660
2g28 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.658
4kxl 6C62'-deoxynucleoside 5'-phosphate N-hydrolase 1 / 0.655
1cm8 ANPMitogen-activated protein kinase 12 / 0.653
2a84 ATPPantothenate synthetase 6.3.2.1 0.653
2y6p CTP3-deoxy-manno-octulosonate cytidylyltransferase 2.7.7.38 0.653
3ez3 IPEFarnesyl pyrophosphate synthase, putative / 0.652