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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2a2x NA9 Prothrombin 3.4.21.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2a2x NA9Prothrombin 3.4.21.5 1.045
2anm CDOProthrombin 3.4.21.5 0.939
4bao MVFProthrombin 3.4.21.5 0.903
2znk 31UProthrombin 3.4.21.5 0.888
4bak M67Prothrombin 3.4.21.5 0.880
4baq M4ZProthrombin 3.4.21.5 0.869
2zfq 45UProthrombin 3.4.21.5 0.860
4bah MELProthrombin 3.4.21.5 0.845
2zg0 50UProthrombin 3.4.21.5 0.843
4bam MM9Prothrombin 3.4.21.5 0.838
2zhq 27UProthrombin 3.4.21.5 0.837
2zda 32UProthrombin 3.4.21.5 0.836
1k22 MELProthrombin 3.4.21.5 0.827
1riw OSCProthrombin 3.4.21.5 0.824
4ban M6SProthrombin 3.4.21.5 0.809
3biu 10UProthrombin 3.4.21.5 0.794
3utu 1TSProthrombin 3.4.21.5 0.783
3biv 11UProthrombin 3.4.21.5 0.778
1nzq 162Prothrombin 3.4.21.5 0.769
2zfr 46UProthrombin 3.4.21.5 0.762
2zhe 13UProthrombin 3.4.21.5 0.760
1c4v IH2Prothrombin 3.4.21.5 0.757
1k21 IGNProthrombin 3.4.21.5 0.756
1kts C24Prothrombin 3.4.21.5 0.731
1o0d 163Prothrombin 3.4.21.5 0.727
2zhw 12UProthrombin 3.4.21.5 0.723
1ypl RA8Prothrombin 3.4.21.5 0.721
1d4p BPPProthrombin 3.4.21.5 0.719
3p17 99PProthrombin 3.4.21.5 0.715
4ayy 9MXProthrombin 3.4.21.5 0.710
1vzq SHYProthrombin 3.4.21.5 0.708
2zi2 24UProthrombin 3.4.21.5 0.708
2ziq 26UProthrombin 3.4.21.5 0.704
2zff 53UProthrombin 3.4.21.5 0.702
1ypk CCRProthrombin 3.4.21.5 0.699
1ypj UIBProthrombin 3.4.21.5 0.698
2zgx 29UProthrombin 3.4.21.5 0.686
4e7r 0NWProthrombin 3.4.21.5 0.684
1ny2 ARG_PRO_PRO_GLYProthrombin 3.4.21.5 0.683
1vja 7INUrokinase-type plasminogen activator 3.4.21.73 0.683
1wqv PSMCoagulation factor VII 3.4.21.21 0.682
3dhk 23UProthrombin 3.4.21.5 0.682
3qto 10PProthrombin 3.4.21.5 0.681
4fud 6UPUrokinase-type plasminogen activator 3.4.21.73 0.681
1ypm RA4Prothrombin 3.4.21.5 0.678
1ta6 177Prothrombin 3.4.21.5 0.677
2cn0 F25Prothrombin 3.4.21.5 0.677
1wtg 3BPCoagulation factor VII 3.4.21.21 0.676
2zp0 PI0Coagulation factor VII 3.4.21.21 0.675
2zhf 49UProthrombin 3.4.21.5 0.674
1ta2 176Prothrombin 3.4.21.5 0.672
1f92 UKPUrokinase-type plasminogen activator 3.4.21.73 0.670
2v3o I26Prothrombin 3.4.21.5 0.669
2gde SN3Prothrombin 3.4.21.5 0.668
1nt1 T76Prothrombin 3.4.21.5 0.666
1u6q 745Urokinase-type plasminogen activator 3.4.21.73 0.665
2r2m I50Prothrombin 3.4.21.5 0.662
4ax9 N5NProthrombin 3.4.21.5 0.661
4az2 9MUProthrombin 3.4.21.5 0.661
1jwt BLIProthrombin 3.4.21.5 0.657
3qtv 06PProthrombin 3.4.21.5 0.657
3dux 64UProthrombin 3.4.21.5 0.656
1ype UIPProthrombin 3.4.21.5 0.654
2cf9 348Prothrombin 3.4.21.5 0.654
2zfp 19UProthrombin 3.4.21.5 0.652
3hat GLY_VAL_ARG_RNGProthrombin 3.4.21.5 0.651
1wv7 5PICoagulation factor VII 3.4.21.21 0.650
2zgb 21UProthrombin 3.4.21.5 0.650
5cmx 0G6Prothrombin 3.4.21.5 0.650