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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1zua TOL Aldo-keto reductase family 1 member B10 1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1zua TOLAldo-keto reductase family 1 member B10 1.1.1 1.024
2fzb TOLAldose reductase 1.1.1.21 0.863
1ah3 TOLAldose reductase 1.1.1.21 0.856
2fzd TOLAldose reductase 1.1.1.21 0.788
2pdc 393Aldose reductase 1.1.1.21 0.680
2pdj 393Aldose reductase 1.1.1.21 0.676
2ikj 393Aldose reductase 1.1.1.21 0.675
3m64 393Aldose reductase 1.1.1.21 0.673
2pdl TOLAldose reductase 1.1.1.21 0.668
2nvc ITAAldose reductase 1.1.1.21 0.661
2pdf ZSTAldose reductase 1.1.1.21 0.650