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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1zh8 NAP Uncharacterized protein

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1zh8 NAPUncharacterized protein / 1.343
5a02 NAPGlucose-fructose oxidoreductase / 0.922
5a06 NDPGlucose-fructose oxidoreductase / 0.901
1h6c NDPGlucose--fructose oxidoreductase 1.1.99.28 0.900
5a05 NDPGlucose-fructose oxidoreductase / 0.891
1evj NADGlucose--fructose oxidoreductase 1.1.99.28 0.883
5a04 NDPGlucose-fructose oxidoreductase / 0.882
2glx NDP1,5-anhydro-D-fructose reductase / 0.876
5a03 NDPGlucose-fructose oxidoreductase / 0.874
1h6a NDPGlucose--fructose oxidoreductase 1.1.99.28 0.868
1ofg NDPGlucose--fructose oxidoreductase 1.1.99.28 0.863
1h6b NDPGlucose--fructose oxidoreductase 1.1.99.28 0.848
1h6d NDPGlucose--fructose oxidoreductase 1.1.99.28 0.845
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.840
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.822
1ryd NDPGlucose--fructose oxidoreductase 1.1.99.28 0.820
3oa2 NADUDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase / 0.778
1rye NDPGlucose--fructose oxidoreductase 1.1.99.28 0.777
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 0.760
3o9z NADLipopolysaccaride biosynthesis protein wbpB / 0.760
2cvz NDP3-hydroxyisobutyrate dehydrogenase / 0.758
5ein NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.757
2f1k NAPPrephenate dehydrogenase / 0.749
3q2k NAIProbable oxidoreductase / 0.735
1mv8 GDXGDP-mannose 6-dehydrogenase 1.1.1.132 0.733
3ec7 NADInositol 2-dehydrogenase / 0.733
3m2t NADProbable dehydrogenase / 0.732
4pxz CLRP2Y purinoceptor 12 / 0.721
5bsf NADPyrroline-5-carboxylate reductase / 0.720
1cf2 NAPGlyceraldehyde-3-phosphate dehydrogenase / 0.719
3tri NAPPyrroline-5-carboxylate reductase / 0.719
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.714
3ikt NADRedox-sensing transcriptional repressor Rex / 0.714
2dbq NAPGlyoxylate reductase 1.1.1.26 0.707
2rcy NAPPyrroline-5-carboxylate reductase / 0.706
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.704
2h63 NAPBiliverdin reductase A 1.3.1.24 0.703
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.702
1q0q NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.701
3sxp NADADP-L-glycero-D-mannoheptose-6-epimerase / 0.701
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.699
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.699
1wp4 NDP3-hydroxyisobutyrate dehydrogenase / 0.698
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.697
5aq1 NDPGlucose-6-phosphate 1-dehydrogenase / 0.694
2j3k NAPNADPH-dependent oxidoreductase 2-alkenal reductase 1.3.1.74 0.693
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.691
1gq2 NAPNADP-dependent malic enzyme 1.1.1.40 0.690
3x2f NAIAdenosylhomocysteinase / 0.689
1vi2 NADQuinate/shikimate dehydrogenase / 0.688
2dbr NAPGlyoxylate reductase 1.1.1.26 0.688
1nah NADUDP-glucose 4-epimerase 5.1.3.2 0.687
2yjz NAPMetalloreductase STEAP4 1.16.1 0.687
4z0p NDPNAD-dependent dehydrogenase / 0.686
1yqd NAPSinapyl alcohol dehydrogenase / 0.685
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.684
3wfj NAD2-dehydropantoate 2-reductase / 0.683
4weq NAPNAD-dependent dehydrogenase / 0.683
2x86 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.682
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.682
3ehe NADUDP-glucose 4-epimerase (GalE-1) / 0.681
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.681
2x6t NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.679
3aw9 NADNAD-dependent epimerase/dehydratase / 0.679
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.679
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.678
3rbv NAPSugar 3-ketoreductase / 0.678
4ej0 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.677
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.677
4xgi NADGlutamate dehydrogenase / 0.677
2ahr NAPPyrroline-5-carboxylate reductase / 0.676
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.675
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.674
3adp NAILambda-crystallin 1.1.1.45 0.674
3had NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.673
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.673
2vq3 NAPMetalloreductase STEAP3 / 0.672
5eio NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.672
1f17 NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.671
3bts NADGalactose/lactose metabolism regulatory protein GAL80 / 0.670
4om8 NAD3-hydroxybutyryl-coA dehydrogenase / 0.670
3ulk NDPKetol-acid reductoisomerase (NADP(+)) / 0.669
4hxy NDPPlm1 / 0.668
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.667
4gae NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.667
5d2e NAPMlnE / 0.666
3baz NAPHydroxyphenylpyruvate reductase 1.1.1.237 0.665
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.665
3pgx NADUncharacterized NAD-dependent oxidoreductase MAP_4146 / 0.665
1n2s NAIdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.664
3cea NADMyo-inositol 2-dehydrogenase-like (Promiscuous) / 0.664
4hwk NAPSepiapterin reductase 1.1.1.153 0.663
3zu2 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.662
1jn0 NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.661
2yy7 NADL-threonine dehydrogenase / 0.661
3kbo NDPGlyoxylate/hydroxypyruvate reductase A / 0.661
3w6u NAP6-phosphogluconate dehydrogenase, NAD-binding protein / 0.661
4c3s NADAldehyde Dehydrogenase / 0.661
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.660
1qmg APXKetol-acid reductoisomerase, chloroplastic 1.1.1.86 0.660
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 0.660
1fxs NAPGDP-L-fucose synthase / 0.659
2o23 NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.659
2c29 NAPDihydroflavonol 4-reductase / 0.658
3tsc NADUncharacterized protein / 0.658
4dbv NDPGlyceraldehyde-3-phosphate dehydrogenase / 0.658
1p9b IMOAdenylosuccinate synthetase / 0.657
3cmc NADGlyceraldehyde-3-phosphate dehydrogenase / 0.657
4gmg NAPYersiniabactin biosynthetic protein YbtU / 0.657
3ru9 NADUDP-N-acetylglucosamine 4-epimerase / 0.656
1dli UDXUDP-glucose 6-dehydrogenase / 0.654
3dzv ADPHydroxyethylthiazole kinase / 0.654
3rua NADUDP-N-acetylglucosamine 4-epimerase / 0.654
1fdu NAPEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.653
1o8c NDPProbable acrylyl-CoA reductase AcuI 1.3.1.84 0.653
2hdh NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.653
3anm NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.653
1rkx NADCDP-D-glucose-4,6-dehydratase / 0.652
3f3s NADLambda-crystallin homolog / 0.652
3ptz UDXUDP-glucose 6-dehydrogenase 1.1.1.22 0.652
4j7u NAPSepiapterin reductase 1.1.1.153 0.652
4kqw NAPKetol-acid reductoisomerase (NADP(+)) / 0.652
3ndr NADPyridoxal 4-dehydrogenase 1.1.1.107 0.651
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.650
2rbe NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.650
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.650