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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1z5m LI8 3-phosphoinositide-dependent protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1z5m LI83-phosphoinositide-dependent protein kinase 1 2.7.11.1 1.048
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.723
3ztx ZTXAurora kinase B-A 2.7.11.1 0.682
2x4f 16XMyosin light chain kinase family member 4 2.7.11.1 0.679
4aot GW8Serine/threonine-protein kinase 10 2.7.11.1 0.679
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 0.678
4aqc 88ATyrosine-protein kinase JAK2 / 0.676
2p33 J07Mitogen-activated protein kinase 10 2.7.11.24 0.675
3cjg KIMVascular endothelial growth factor receptor 2 2.7.10.1 0.674
3efw AK8Aurora kinase A 2.7.11.1 0.665
2x81 ZZLAurora kinase A 2.7.11.1 0.664
1oec AA2Fibroblast growth factor receptor 2 / 0.663
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.663
4iwo 1H4Serine/threonine-protein kinase TBK1 2.7.11.1 0.659
4fsw HK6Serine/threonine-protein kinase Chk1 2.7.11.1 0.657
3cjf SAVVascular endothelial growth factor receptor 2 2.7.10.1 0.654
4f4p 0SBTyrosine-protein kinase SYK 2.7.10.2 0.654
4bbe 3O4Tyrosine-protein kinase JAK2 / 0.651
4b0g VEKAurora kinase A 2.7.11.1 0.650
5dt0 SKEAurora kinase A 2.7.11.1 0.650