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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1z1h HBB Gag-Pol polyprotein 3.4.23.16

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
1z1h HBBGag-Pol polyprotein 3.4.23.16 1.256
2qi5 MZ7Gag-Pol polyprotein / 1.023
3sa9 A68Protease / 0.987
1z1r HBHGag-Pol polyprotein 3.4.23.16 0.976
3st5 G89Gag-Pol polyprotein 3.4.23.16 0.970
3vfa 031Gag-Pol polyprotein 3.4.23.16 0.965
3qaa G04Gag-Pol polyprotein 3.4.23.16 0.964
2qi0 MZ3Gag-Pol polyprotein / 0.958
2psu MUUProtease / 0.951
3eky DR7Gag-Pol polyprotein 3.4.23.16 0.936
3mws 017Pol protein / 0.933
3pwm 017Gag-Pol polyprotein 3.4.23.16 0.924
3sa7 55AProtease / 0.916
1d4l PI9Gag-Pol polyprotein 3.4.23.16 0.915
4dfg 0JVGag-Pol polyprotein 3.4.23.16 0.915
3el1 DR7Gag-Pol polyprotein 3.4.23.16 0.912
4kb9 G79Protease / 0.910
3o9a K14Pol polyprotein / 0.905
4hdp G52Gag-Pol polyprotein 3.4.23.16 0.895
2f80 017Gag-Pol polyprotein 3.4.23.16 0.894
3sab F78Protease / 0.894
3o9f K2DGag-Pol polyprotein / 0.891
3sa3 23XProtease / 0.891
3el9 DR7Gag-Pol polyprotein 3.4.23.16 0.886
2z4o 065Gag-Pol polyprotein 3.4.23.16 0.880
3jvy 017Gag-Pol polyprotein 3.4.23.16 0.880
3o9b K2APol polyprotein / 0.880
2qci 065Gag-Pol polyprotein 3.4.23.16 0.878
3vf5 031Gag-Pol polyprotein 3.4.23.16 0.876
4djo MK5Pol polyprotein / 0.876
4dqc 017Gag-Pol polyprotein / 0.871
3sa5 A69Protease / 0.870
4hdf G52Gag-Pol polyprotein 3.4.23.16 0.865
2fxe DR7Gag-Pol polyprotein 3.4.23.16 0.863
2qhy MZ1Gag-Pol polyprotein / 0.862
4dqh 017Gag-Pol polyprotein / 0.860
3o9e A60Pol polyprotein / 0.858
3oxx DR7Gag-Pol polyprotein 3.4.23.16 0.856
3oy4 017Gag-Pol polyprotein 3.4.23.16 0.851
3kfn 3TLGag-Pol polyprotein / 0.850
2qd7 065Gag-Pol polyprotein 3.4.23.16 0.849
1t3r 017Gag-Pol polyprotein 3.4.23.16 0.847
3i7e DJRGag-Pol polyprotein / 0.847
3lzv 017Gag-Pol polyprotein 3.4.23.16 0.847
4heg G52Gag-Pol polyprotein 3.4.23.16 0.847
1ida 0POGag-Pol polyprotein 3.4.23.47 0.846
4njs G08Protease / 0.845
2idw 017Protease / 0.844
2qd8 065Gag-Pol polyprotein 3.4.23.16 0.844
3r4b 74TGag-Pol polyprotein / 0.843
2fdd 385Pol protein / 0.841
2qd6 065Gag-Pol polyprotein 3.4.23.16 0.841
3ok9 G52Gag-Pol polyprotein 3.4.23.16 0.841
4dqe 017Gag-Pol polyprotein / 0.841
3i6o GR6Gag-Pol polyprotein 3.4.23.16 0.839
2hs2 017Protease / 0.838
3lzu 017Gag-Pol polyprotein 3.4.23.16 0.837
3o9d K19Pol polyprotein / 0.836
3o9h K2EGag-Pol polyprotein / 0.836
2hb3 GRLProtease / 0.835
4djp M73Pol polyprotein / 0.834
2f81 017Gag-Pol polyprotein 3.4.23.16 0.833
3em3 478Gag-Pol polyprotein 3.4.23.16 0.830
3o9i A61Gag-Pol polyprotein / 0.830
4dqb 017Gag-Pol polyprotein / 0.830
3o9c K20Pol polyprotein / 0.827
3em4 DR7Gag-Pol polyprotein 3.4.23.16 0.825
2i4u DJRProtease / 0.824
2f8g 017Gag-Pol polyprotein 3.4.23.16 0.823
3oxw 017Gag-Pol polyprotein 3.4.23.16 0.823
3nu9 478Gag-Pol polyprotein 3.4.23.16 0.821
4dqf 017Gag-Pol polyprotein / 0.820
4q1w 017Gag-Pol polyprotein 3.4.23.16 0.820
4hdb G52Gag-Pol polyprotein 3.4.23.16 0.819
3sa4 F72Protease / 0.818
3ecg 065Gag-Pol polyprotein 3.4.23.47 0.817
3s85 LK0Gag-Pol polyprotein / 0.815
4i8z G08Gag-Pol polyprotein 3.4.23.16 0.813
2a1e IPFGag-Pol polyprotein 3.4.23.16 0.812
3mxe K54Gag-Pol polyprotein 3.4.23.16 0.812
3kfs 3TLGag-Pol polyprotein / 0.810
3t3c 017Gag-Pol polyprotein 3.4.23.16 0.810
3mxd K53Gag-Pol polyprotein 3.4.23.16 0.809
3o99 K13Pol polyprotein / 0.809
2qi4 MZ6Gag-Pol polyprotein / 0.808
3gi4 K60Gag-Pol polyprotein / 0.808
3kfr 3TLGag-Pol polyprotein / 0.808
3sa8 K83Protease / 0.808
1npv L27Gag-Pol polyprotein 3.4.23.16 0.807
2psv MUVProtease / 0.806
3tl9 ROCGag-Pol polyprotein 3.4.23.16 0.806
1a8g 2Z4Gag-Pol polyprotein 3.4.23.16 0.805
2cen 4AHProtease / 0.805
3ekt 017Gag-Pol polyprotein 3.4.23.16 0.805
2hs1 017Protease / 0.803
4djr 0KJPol polyprotein / 0.803
4q1y 017Gag-Pol polyprotein 3.4.23.16 0.803
3ekv 478Gag-Pol polyprotein 3.4.23.16 0.802
2aqu DR7Gag-Pol polyprotein 3.4.23.16 0.801
3cyw 017Gag-Pol polyprotein 3.4.23.16 0.800
3gi6 D78Gag-Pol polyprotein / 0.800
1b6l PI4Gag-Pol polyprotein 3.4.23.16 0.799
3vf7 031Gag-Pol polyprotein 3.4.23.16 0.799
1iiq 0ZRGag-Pol polyprotein 3.4.23.16 0.798
3sac AF8Protease / 0.798
4j54 G52Gag-Pol polyprotein 3.4.23.16 0.798
2i4x KGQProtease / 0.797
1b6k PI5Gag-Pol polyprotein 3.4.23.16 0.796
3d1z 017Gag-Pol polyprotein 3.4.23.16 0.795
1hii C20Gag-Pol polyprotein / 0.794
1t7i 017Gag-Pol polyprotein 3.4.23.16 0.794
3dk1 G05Gag-Pol polyprotein 3.4.23.16 0.791
2i4d QFIProtease / 0.789
3d1y ROCGag-Pol polyprotein 3.4.23.16 0.789
1fff 0Q4Gag-Pol polyprotein 3.4.23.16 0.788
1hvs A77Gag-Pol polyprotein / 0.788
3oxv 478Gag-Pol polyprotein 3.4.23.16 0.788
3slz 3TLPutative gag-pro-pol polyprotein / 0.787
1hih C20Gag-Pol polyprotein / 0.784
4q1x 017Gag-Pol polyprotein 3.4.23.16 0.784
3s54 017Protease / 0.783
2qak 1UNGag-Pol polyprotein 3.4.23.16 0.782
2qi6 MZ8Gag-Pol polyprotein / 0.782
3jw2 017Gag-Pol polyprotein 3.4.23.16 0.782
3saa 77FProtease / 0.782
1b6m PI6Gag-Pol polyprotein 3.4.23.16 0.780
1b6p PI7Gag-Pol polyprotein 3.4.23.16 0.780
2p3c 3TLProtease / 0.779
3sm2 478Putative gag-pro-pol polyprotein / 0.779
2ieo 017Protease / 0.778
3vfb 031Gag-Pol polyprotein 3.4.23.16 0.778
3gga GGWGag-Pol polyprotein / 0.777
3nxe 2NCProtease / 0.777
3sa6 F71Protease / 0.777
3ggu 017Gag-Pol polyprotein 3.4.23.16 0.776
3kf0 3TLGag-Pol polyprotein / 0.776
1mrw K57Gag-Pol polyprotein 3.4.23.16 0.775
4hla 017Gag-Pol polyprotein 3.4.23.16 0.775
2qi3 MZ5Gag-Pol polyprotein / 0.774
3nuo 478Gag-Pol polyprotein 3.4.23.16 0.772
1fej 2NCGag-Pol polyprotein 3.4.23.16 0.770
2fle AIProtease / 0.770
1izh Q50Protease / 0.769
2nmy ROCProtease / 0.769
2qi7 MZ9Gag-Pol polyprotein / 0.769
3d20 017Gag-Pol polyprotein 3.4.23.16 0.769
4ye3 G04Gag-Pol polyprotein 3.4.23.16 0.769
2fde 385Gag-Pol polyprotein 3.4.23.16 0.768
2aoe 0Q4Gag-Pol polyprotein 3.4.23.16 0.766
1mtr PI6Gag-Pol polyprotein 3.4.23.16 0.765
1k6t XN1Gag-Pol polyprotein 3.4.23.16 0.763
1tcx IM1Gag-Pol polyprotein 3.4.23.16 0.763
2fxd DR7Pol polyprotein / 0.763
3k4v ROCGag-Pol polyprotein 3.4.23.16 0.762
3nu4 478Gag-Pol polyprotein 3.4.23.16 0.762
2nnp ROCProtease / 0.761
3lzs 017Gag-Pol polyprotein 3.4.23.16 0.761
3nu3 478Gag-Pol polyprotein 3.4.23.16 0.761
3ucb 017Gag-Pol polyprotein / 0.761
3s56 ROCProtease / 0.760
1a94 0Q4Gag-Pol polyprotein 3.4.23.16 0.759
1dw6 0Q4Gag-Pol polyprotein 3.4.23.16 0.759
4j5j 478Gag-Pol polyprotein 3.4.23.16 0.759
1hvl A76Gag-Pol polyprotein / 0.758
2q63 1UNGag-Pol polyprotein 3.4.23.16 0.758
4djq M86Pol polyprotein / 0.758
1ec3 MS3Gag-Pol polyprotein 3.4.23.16 0.757
1pro A88Gag-Pol polyprotein / 0.757
2ien 017Gag-Pol polyprotein 3.4.23.16 0.757
4njt 017Protease / 0.757
1yt9 OISGag-Pol polyprotein / 0.751
1sdv MK1Gag-Pol polyprotein 3.4.23.16 0.750
1ffi 2NCGag-Pol polyprotein 3.4.23.16 0.747
3nu6 478Gag-Pol polyprotein 3.4.23.16 0.747
1siv PSIGag-Pol polyprotein / 0.746
1ohr 1UNV-1 PROTEASE protein / 0.745
2pym 1UNGag-Pol polyprotein 3.4.23.16 0.745
3bxr DRRGag-Pol polyprotein 3.4.23.16 0.742
1sdt MK1Gag-Pol polyprotein 3.4.23.16 0.741
1sdu MK1Gag-Pol polyprotein 3.4.23.16 0.741
2cem 2AHPol protein / 0.741
2i0d MUTProtease / 0.741
1mes DMPGag-Pol polyprotein 3.4.23.16 0.740
1sbg IM1Gag-Pol polyprotein / 0.740
2i0a MUIProtease / 0.740
2p3d 3TLProtease / 0.740
3ufn ROCGag-Pol polyprotein / 0.740
3nuj 478Gag-Pol polyprotein 3.4.23.16 0.737
3nwx KVSGag-Pol polyprotein 3.4.23.16 0.736
1d4i BEGGag-Pol polyprotein 3.4.23.16 0.735
2wkz 5AHGag-Pol polyprotein / 0.735
1hpv 478Gag-Pol polyprotein / 0.734
1g35 AHFGag-Pol polyprotein 3.4.23.16 0.733
2avv MK1Gag-Pol polyprotein 3.4.23.16 0.731
3ekq ROCGag-Pol polyprotein 3.4.23.16 0.731
1daz 0Q4Gag-Pol polyprotein 3.4.23.16 0.730
3jvw DMPGag-Pol polyprotein 3.4.23.16 0.730
4j55 031Gag-Pol polyprotein 3.4.23.16 0.729
1bdr IM1Gag-Pol polyprotein 3.4.23.16 0.728
2b60 RITPol polyprotein / 0.728
3nu5 478Gag-Pol polyprotein 3.4.23.16 0.726
1ebk 0Q4Gag-Pol polyprotein 3.4.23.16 0.724
1fg6 2NCGag-Pol polyprotein 3.4.23.16 0.724
3dck KVIProtease / 0.724
3dcr KVSProtease / 0.724
3el4 ROCGag-Pol polyprotein 3.4.23.16 0.724
4qgi ROCGag-Pol polyprotein 3.4.23.16 0.723
1npa 3NHGag-Pol polyprotein 3.4.23.16 0.722
1npw LGZGag-Pol polyprotein 3.4.23.16 0.722
2nnk ROCProtease / 0.721
3djk G55Gag-Pol polyprotein 3.4.23.16 0.721
3ndw RITGag-Pol polyprotein 3.4.23.16 0.721
3s43 478Protease / 0.720
3gi5 K62Gag-Pol polyprotein / 0.718
3i2l 2NCProtease / 0.718
1hvr XK2Gag-Pol polyprotein / 0.716
2avs MK1Gag-Pol polyprotein 3.4.23.16 0.716
4njv RITProtease / 0.715
2cej 1AHPol protein / 0.713
2f3k RO1Protease / 0.713
1ff0 2NCGag-Pol polyprotein 3.4.23.16 0.712
4rvj 478Protease / 0.711
1mer DMQGag-Pol polyprotein 3.4.23.16 0.709
2q54 MU1Protease / 0.707
1m0b 0ZQGag-Pol polyprotein 3.4.23.16 0.706
2i4v DJRV-1 protease / 0.705
1fgc 2NCGag-Pol polyprotein 3.4.23.16 0.704
3bva 2NCGag-Pol polyprotein 3.4.23.16 0.703
3cyx ROCGag-Pol polyprotein 3.4.23.16 0.703
1wbm BLLPol protein / 0.702
3d1x ROCGag-Pol polyprotein 3.4.23.16 0.702
2bb9 AKCGag-Pol polyprotein 3.4.23.16 0.701
1izi Q50Gag-Pol polyprotein 3.4.23.16 0.700
2q5k AB1Protease / 0.700
1k2c 0Q4Gag-Pol polyprotein 3.4.23.16 0.699
2i4w KGQProtease / 0.697
1hiv 1ZKGag-Pol polyprotein / 0.696
1hxw RITGag-Pol polyprotein / 0.695
3bvb 017Gag-Pol polyprotein 3.4.23.16 0.695
3ekw DR7Gag-Pol polyprotein 3.4.23.16 0.695
3nyg 2NCGag-Pol polyprotein 3.4.23.16 0.695
2avm 2NCGag-Pol polyprotein 3.4.23.16 0.694
1hvj A78Gag-Pol polyprotein / 0.692
1qbr XV6Gag-Pol polyprotein 3.4.23.16 0.692
3bxs DRSGag-Pol polyprotein 3.4.23.16 0.692
1idb 0DOGag-Pol polyprotein / 0.691
1ajv NMBGag-Pol polyprotein 3.4.23.16 0.689
4a4q UX9Pol protein / 0.688
1qbs DMPGag-Pol polyprotein 3.4.23.16 0.686
3ndx RITGag-Pol polyprotein 3.4.23.16 0.685
1n49 RITGag-Pol polyprotein 3.4.23.16 0.684
3kdd JZQGag-Pol polyprotein 3.4.23.16 0.684
1ebz BECGag-Pol polyprotein 3.4.23.16 0.683
2q64 1UNGag-Pol polyprotein 3.4.23.16 0.682
1ec1 BEEGag-Pol polyprotein 3.4.23.16 0.681
1hwr 216Gag-Pol polyprotein 3.4.23.16 0.681
1rl8 RITGag-Pol polyprotein 3.4.23.16 0.680
2bpw 1INGag-Pol polyprotein 3.4.23.16 0.680
3a2o KNJGag-Pol polyprotein 3.4.23.16 0.680
3wsj MK1Protease / 0.680
1dmp DMQGag-Pol polyprotein 3.4.23.16 0.679
3ekp 478Gag-Pol polyprotein 3.4.23.16 0.678
2fmb LP1Reverse transcriptase / 0.677
3ggx GGXGag-Pol polyprotein / 0.676
1hsh MK1Gag-Pol polyprotein / 0.674
1hos PHPGag-Pol polyprotein / 0.673
2bpx MK1Gag-Pol polyprotein 3.4.23.16 0.673
3o9g F53Gag-Pol polyprotein / 0.672
2hc0 AB2Protease / 0.668
2uxz HI1Gag-Pol polyprotein 3.4.23.16 0.668
1a9m U0EGag-Pol polyprotein / 0.667
1fg8 0Q4Gag-Pol polyprotein 3.4.23.16 0.667
1zsf 0ZSGag-Pol polyprotein 3.4.23.16 0.667
1bdq IM1Gag-Pol polyprotein 3.4.23.16 0.666
1d4h BEHGag-Pol polyprotein 3.4.23.16 0.665
3kdc JZPGag-Pol polyprotein 3.4.23.16 0.665
1ivp 1ZKGag-Pol polyprotein / 0.664
2wl0 5AHGag-Pol polyprotein / 0.664
2q55 MU0Protease / 0.663
3pwr ROCGag-Pol polyprotein 3.4.23.16 0.663
1hpx KNIGag-Pol polyprotein / 0.662
1zsr 0ZTGag-Pol polyprotein 3.4.23.16 0.661
2uy0 HV1Gag-Pol polyprotein 3.4.23.16 0.661
1bv7 XV6Gag-Pol polyprotein 3.4.23.16 0.660
2r3t G4GGag-Pol polyprotein 3.4.23.16 0.660
2r5p MK1Gag-Pol polyprotein / 0.659
1k6p XN3Gag-Pol polyprotein 3.4.23.16 0.655
3bgb LJGGag-Pol polyprotein 3.4.23.16 0.655
1w5y BE6Gag-Pol polyprotein 3.4.23.16 0.654
1dif A85Gag-Pol polyprotein / 0.652
1k2b 0Q4Gag-Pol polyprotein 3.4.23.16 0.650
2p3a 3TLPol protein / 0.650
3ekx 1UNGag-Pol polyprotein 3.4.23.16 0.650
4a6b QG8Gag-Pol polyprotein 3.4.23.16 0.650