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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1yb5 NAP Quinone oxidoreductase 1.6.5.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1yb5 NAPQuinone oxidoreductase 1.6.5.5 1.318
3tqh NDPQuinone oxidoreductase / 0.812
4b7x NAPProbable oxidoreductase / 0.791
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.790
2j3k NAPNADPH-dependent oxidoreductase 2-alkenal reductase 1.3.1.74 0.757
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.752
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.746
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.742
4rvu NDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) / 0.740
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.739
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.738
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.737
1x7d NADPutative ornithine cyclodeaminase / 0.736
4jbi NDPAlcohol dehydrogenase (Zinc) / 0.734
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.733
3wle NAD(R)-specific carbonyl reductase / 0.731
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.728
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.728
1u7h NADPutative ornithine cyclodeaminase / 0.727
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.727
4y0k NAPAntE / 0.724
4xq9 NADHomospermidine synthase 2.5.1.44 0.723
4y1b NAPAntE / 0.722
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.722
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.720
1uxk NADMalate dehydrogenase / 0.720
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.719
3jv7 NADSecondary alcohol dehydrogenase / 0.716
2zb3 NDPProstaglandin reductase 2 1.3.1.48 0.714
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.713
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.712
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.711
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.711
4plp NADHomospermidine synthase 2.5.1.44 0.710
4c4o NADSADH / 0.709
4j49 NADUncharacterized protein / 0.709
4xqc NADHomospermidine synthase 2.5.1.44 0.709
4j43 NADUncharacterized protein / 0.708
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.708
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.708
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.707
4xrg NADHomospermidine synthase 2.5.1.44 0.707
1yqd NAPSinapyl alcohol dehydrogenase / 0.705
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.705
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.704
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.704
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.700
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.700
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.699
4j4b NAIUncharacterized protein / 0.699
4k28 NADShikimate dehydrogenase family protein / 0.698
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.698
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.697
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.696
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.695
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.695
2b5v NAPGlucose 1-dehydrogenase / 0.695
3anm NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.695
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.694
3slk NDPPolyketide synthase extender module 2 / 0.693
4tvb NADHomospermidine synthase 2.5.1.44 0.692
4hwk NAPSepiapterin reductase 1.1.1.153 0.691
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.690
1yqx NAPSinapyl alcohol dehydrogenase / 0.690
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.690
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.690
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.688
2o4c NADErythronate-4-phosphate dehydrogenase / 0.685
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.684
1uxj NADMalate dehydrogenase / 0.683
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.683
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.683
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.683
1gv0 NADMalate dehydrogenase / 0.682
3jyn NDPQuinone oxidoreductase / 0.682
5dul NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.682
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.681
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.680
4yal 2AMNADPH--cytochrome P450 reductase / 0.679
1sow NADL-lactate dehydrogenase 1.1.1.27 0.678
2vna NAPProstaglandin reductase 2 1.3.1.48 0.678
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.678
1f8f NADBenzyl alcohol dehydrogenase / 0.677
1o6z NADMalate dehydrogenase / 0.677
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.675
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.675
2c0c NAPProstaglandin reductase 3 1 0.673
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.672
4jk3 NADUncharacterized protein / 0.671
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.669
3nx4 NAPPutative oxidoreductase / 0.669
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.668
4cpd NADAlcohol dehydrogenase / 0.666
3au8 NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.665
4j7x NAPSepiapterin reductase 1.1.1.153 0.665
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.665
4yaf 2AMNADPH--cytochrome P450 reductase / 0.665
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.664
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.663
2j3i NAPNADPH-dependent oxidoreductase 2-alkenal reductase 1.3.1.74 0.663
1guf NDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial 1.3.1.10 0.662
1wzi NDPMalate dehydrogenase / 0.660
3q3c NADNAD-dependent L-serine dehydrogenase / 0.660
5dp2 NAPCurF / 0.660
1vc2 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.659
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.659
3w6u NAP6-phosphogluconate dehydrogenase, NAD-binding protein / 0.659
4i1i NADMalate dehydrogenase / 0.659
1pjc NADAlanine dehydrogenase / 0.658
4e5m NAPPhosphonate dehydrogenase 1.20.1.1 0.658
2ev9 NAPShikimate dehydrogenase (NADP(+)) / 0.657
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.657
1q0q NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.655
1ur5 NADMalate dehydrogenase / 0.655
1wze NADMalate dehydrogenase / 0.655
2x0r NADMalate dehydrogenase / 0.655
1i3l NADUDP-glucose 4-epimerase / 0.653
4yau 2AMNADPH--cytochrome P450 reductase / 0.653
4rqu NADAlcohol dehydrogenase class-P / 0.652
4gi2 NAPCrotonyl-CoA carboxylase/reductase / 0.651
4yao 2AMNADPH--cytochrome P450 reductase / 0.651
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.650
1guy NADMalate dehydrogenase / 0.650
2y05 NAPProstaglandin reductase 1 / 0.650