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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ya3 STR Mineralocorticoid receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ya3 STRMineralocorticoid receptor / 1.115
2aa6 STRMineralocorticoid receptor / 0.886
2ab2 SNLMineralocorticoid receptor / 0.829
2abi 1CAMineralocorticoid receptor / 0.816
2aa7 1CAMineralocorticoid receptor / 0.797
2aa5 STRMineralocorticoid receptor / 0.768
1y9r 1CAMineralocorticoid receptor / 0.762
3vhu SNLMineralocorticoid receptor / 0.750
2a3i C0RMineralocorticoid receptor / 0.739
4p6x HCYGlucocorticoid receptor / 0.715
4j6b PLOCytochrome P450 monooxygenase / 0.713
4ofr DHTAndrogen receptor / 0.712
1p93 DEXGlucocorticoid receptor / 0.711
1kdm DHTSex hormone-binding globulin / 0.710
1m2z DEXGlucocorticoid receptor / 0.710
2j7x ESTEstrogen receptor beta / 0.701
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.698
3cot STR3-oxo-5-beta-steroid 4-dehydrogenase / 0.697
3gkj HC3Niemann-Pick C1 protein / 0.695
2aba STRPentaerythritol tetranitrate reductase / 0.684
3s79 ASDAromatase 1.14.14.14 0.684
4a2j AS0Progesterone receptor / 0.681
3eqm ASDAromatase 1.14.14.14 0.680
4p6w MOFGlucocorticoid receptor / 0.680
5dxg ESTEstrogen receptor / 0.679
3cas ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.676
3d90 NOGProgesterone receptor / 0.674
3oll ESTEstrogen receptor beta / 0.673
1f5f DHTSex hormone-binding globulin / 0.667
2cbo TH2Neocarzinostatin / 0.666
1nhz 486Glucocorticoid receptor / 0.661
2mm3 CHOGastrotropin / 0.661
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.660
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
2puc GUNHTH-type transcriptional repressor PurR / 0.660
4e5i 0N9Polymerase acidic protein / 0.660
4e5l DBHPolymerase acidic protein / 0.660
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.660
4e5f 0N7Polymerase acidic protein / 0.659
5epo TUD7-alpha-hydroxysteroid deydrogenase / 0.658
1coy ANDCholesterol oxidase 1.1.3.6 0.657
2yja ESTEstrogen receptor / 0.657
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.657
2aax PDNMineralocorticoid receptor / 0.655
1p0e PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.654
2ocf ESTEstrogen receptor / 0.654
3l0l HC3Nuclear receptor ROR-gamma / 0.654
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.653
2z1x PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.653
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.653
3zqt TESAndrogen receptor / 0.653
4udc DEXGlucocorticoid receptor / 0.653
5hyr ESTEstrogen receptor / 0.653
1y5r C0RCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.652
3zux TCHTransporter / 0.652
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.651
3uud ESTEstrogen receptor / 0.651
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.651
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.651