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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1xu7 CPS Corticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1xu7 CPSCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 1.461
1xu9 CPSCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 1.224
1osv CHCBile acid receptor / 0.796
3f3y 4OABile salt sulfotransferase 2.8.2.14 0.777
4q0a 4OAVitamin D3 receptor A / 0.769
2mm3 GCHGastrotropin / 0.742
4ple CPSNuclear receptor subfamily 5 group A member 2 / 0.739
3w5t LHPVitamin D3 receptor / 0.733
3cav CI23-oxo-5-beta-steroid 4-dehydrogenase / 0.722
3w5p 4OAVitamin D3 receptor / 0.721
3w5q 3KLVitamin D3 receptor / 0.710
4qe6 JN3Bile acid receptor / 0.707
3w5r LOAVitamin D3 receptor / 0.706
1o1v TCHGastrotropin / 0.704
3uzx AOM3-oxo-5-beta-steroid 4-dehydrogenase / 0.704
2pit DHTAndrogen receptor / 0.701
4oed DHTAndrogen receptor / 0.701
2ft9 CHDFatty acid-binding protein 2, liver / 0.697
2ama DHTAndrogen receptor / 0.693
1t74 DHTAndrogen receptor / 0.689
4c49 HCYCorticosteroid-binding globulin / 0.689
4ofr DHTAndrogen receptor / 0.689
3bej MUFBile acid receptor / 0.687
2pkl DHTAndrogen receptor / 0.686
2b03 TUDPhospholipase A2, major isoenzyme 3.1.1.4 0.684
4bqu CLRJapanin / 0.684
3k9v CPS1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial / 0.683
5hyr ESTEstrogen receptor / 0.683
4oea DHTAndrogen receptor / 0.680
4oey DHTAndrogen receptor / 0.680
1xj7 DHTAndrogen receptor / 0.678
2lba CHOFatty acid binding protein 6 / 0.676
2pnu ENMAndrogen receptor / 0.676
2z4j DHTAndrogen receptor / 0.675
3gki CLRNiemann-Pick C1 protein / 0.675
3nhx ASDSteroid Delta-isomerase 5.3.3.1 0.674
2pix DHTAndrogen receptor / 0.673
2piv DHTAndrogen receptor / 0.670
1t5z DHTAndrogen receptor / 0.668
1t73 DHTAndrogen receptor / 0.667
4a84 DXCMajor pollen allergen Bet v 1-A / 0.667
2ylp TESAndrogen receptor / 0.666
1t7r DHTAndrogen receptor / 0.665
2opx DXCLactaldehyde dehydrogenase 1.2.1.22 0.660
2pio DHTAndrogen receptor / 0.660
2q7i TESAndrogen receptor / 0.660
2q7k TESAndrogen receptor / 0.659
1t7t DHTAndrogen receptor / 0.658
3gyu DL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily / 0.658
2pip DHTAndrogen receptor / 0.655
2ocf ESTEstrogen receptor / 0.654
2y02 Y01Beta-1 adrenergic receptor / 0.654
1d2s DHTSex hormone-binding globulin / 0.653
1t63 DHTAndrogen receptor / 0.653
4mbl 26LSerine/threonine-protein kinase pim-1 2.7.11.1 0.653
1t7f DHTAndrogen receptor / 0.652
2aib ERGBeta-elicitin cinnamomin / 0.652
2pir DHTAndrogen receptor / 0.652
1gwr ESTEstrogen receptor / 0.651
2piu DHTAndrogen receptor / 0.651
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.650