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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1xor ZAR cAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1xor ZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 1.003
3k4s 0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 0.758
1xoq ROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 0.732
2fm5 M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 0.699
1mkd ZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 0.698
1q9m ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 0.697
3iak EV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 0.677
1y2e 5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 0.667
1y2k 7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 0.653
1oyn ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.1.4.53 0.650