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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1wur 8DG GTP cyclohydrolase 1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1wur 8DGGTP cyclohydrolase 1 / 1.277
1wuq 8GTGTP cyclohydrolase 1 / 1.198
1a8r GTPGTP cyclohydrolase 1 3.5.4.16 0.874
1n3r GTPGTP cyclohydrolase 1 3.5.4.16 0.847
1a9c GTPGTP cyclohydrolase 1 3.5.4.16 0.813
1n3s GTPGTP cyclohydrolase 1 3.5.4.16 0.714
3rv3 ADPBiotin carboxylase 6.3.4.14 0.691
3rup ADPBiotin carboxylase 6.3.4.14 0.686
1ytm ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.682
4kqs RISFarnesyl pyrophosphate synthase 2.5.1.10 0.679
1fnd A2PFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.671
3icr COACoenzyme A disulfide reductase / 0.662
3ics COACoenzyme A disulfide reductase / 0.660
3lzx NAPFerredoxin--NADP reductase 2 1.18.1.2 0.657
4m5p FMNNADPH dehydrogenase / 0.657
4du6 GTPGTP cyclohydrolase 1 / 0.654
1b5d DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.653
1rqj RISFarnesyl diphosphate synthase 2.5.1.10 0.653
4hs4 FMNChromate reductase / 0.653
3u9e COALmo1369 protein / 0.650
4ho3 TTPGlucose-1-phosphate thymidylyltransferase / 0.650