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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1wam FAD UDP-galactopyranose mutase 5.4.99.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1wam FADUDP-galactopyranose mutase 5.4.99.9 1.441
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 1.401
2bi7 FADUDP-galactopyranose mutase 5.4.99.9 1.285
3kyb FADUDP-galactopyranose mutase 5.4.99.9 1.184
3int FDAUDP-galactopyranose mutase 5.4.99.9 1.171
4mo2 FDAUDP-galactopyranose mutase / 0.992
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.976
4mo2 FADUDP-galactopyranose mutase / 0.952
3he3 FADUDP-galactopyranose mutase / 0.915
2yg7 FADPutrescine oxidase / 0.861
2dw4 FADLysine-specific histone demethylase 1A 1 0.849
3hdy FADUDP-galactopyranose mutase / 0.836
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.829
2yg3 FADPutrescine oxidase / 0.825
4i58 FADCyclohexylamine Oxidase / 0.825
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.819
2jae FADL-amino acid oxidase / 0.818
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.816
4rpj FADUDP-galactopyranose mutase 5.4.99.9 0.816
4u8i FDAUDP-galactopyranose mutase / 0.816
2y48 FADLysine-specific histone demethylase 1A 1 0.815
4u8m FDAUDP-galactopyranose mutase / 0.812
4dsg FADUncharacterized protein / 0.810
3qj4 FADRenalase / 0.808
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.804
3utg FDAUDP-galactopyranose mutase / 0.802
4dsh FDAUncharacterized protein / 0.802
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.797
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.792
2yg6 FADPutrescine oxidase / 0.792
3rha FDAPutrescine oxidase / 0.792
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.789
1f8s FADL-amino-acid oxidase 1.4.3.2 0.788
4guu FA9Lysine-specific histone demethylase 1B 1 0.783
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.780
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.780
4gut FADLysine-specific histone demethylase 1B 1 0.778
4gdp FADPolyamine oxidase FMS1 / 0.773
3uth FDAUDP-galactopyranose mutase / 0.770
2jb1 FADL-amino acid oxidase / 0.769
2jb2 FADL-amino acid oxidase / 0.768
2yg4 FADPutrescine oxidase / 0.766
3kve FADL-amino-acid oxidase / 0.765
5br7 FADUDP-galactopyranose mutase / 0.763
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.758
3k7t FAD6-hydroxy-L-nicotine oxidase / 0.756
3cty FADProbable thioredoxin reductase / 0.755
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.754
2c4c FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.753
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.751
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.750
3nn6 FB06-hydroxy-L-nicotine oxidase / 0.750
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.749
4gus FADLysine-specific histone demethylase 1B 1 0.748
4rph FADUDP-galactopyranose mutase 5.4.99.9 0.745
2e1m FADL-glutamate oxidase / 0.742
3hdy FDAUDP-galactopyranose mutase / 0.742
4fwf FADLysine-specific histone demethylase 1B 1 0.742
5l3d FADLysine-specific histone demethylase 1A 1 0.741
3ukf FDAUDP-galactopyranose mutase / 0.739
4rpg FADUDP-galactopyranose mutase 5.4.99.9 0.739
2gv8 FADThiol-specific monooxygenase 1.14.13 0.738
4u8o FDAUDP-galactopyranose mutase / 0.737
2yvj FADFerredoxin reductase / 0.736
3kpf FADPolyamine oxidase 1.5.3.14 0.736
4fwj FADLysine-specific histone demethylase 1B 1 0.735
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.733
3ict FADCoenzyme A disulfide reductase / 0.730
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.729
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.729
1f8r FADL-amino-acid oxidase 1.4.3.2 0.727
2vvl FADMonoamine oxidase N 1.4.3.4 0.727
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.727
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.726
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.726
1z6l FADPolyamine oxidase FMS1 / 0.725
1yy5 FADPolyamine oxidase FMS1 / 0.724
3ka7 FADPutative oxidoreductase / 0.723
4ap3 FADSteroid monooxygenase / 0.723
4fwe FADLysine-specific histone demethylase 1B 1 0.723
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.720
4ech FADPolyamine oxidase FMS1 / 0.720
4mok FADPyranose 2-oxidase / 0.720
1get FADGlutathione reductase 1.8.1.7 0.718
4mih FADPyranose 2-oxidase 1.1.3.10 0.717
1tdk FADL-amino-acid oxidase 1.4.3.2 0.716
4gur FADLysine-specific histone demethylase 1B 1 0.716
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.714
4tm1 FDAKtzI / 0.714
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.714
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.713
1npx FADNADH peroxidase 1.11.1.1 0.713
2gvc FADThiol-specific monooxygenase 1.14.13 0.713
2qa1 FADPgaE / 0.713
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.713
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.712
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.712
4u2t FADCholesterol oxidase 1.1.3.6 0.712
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.709
4jq9 FADDihydrolipoyl dehydrogenase / 0.708
3bi2 FADPolyamine oxidase FMS1 / 0.707
4tm4 FDAKtzI / 0.707
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.706
2gqw FADFerredoxin reductase / 0.706
3cnj FADCholesterol oxidase 1.1.3.6 0.706
3cnt FADPolyamine oxidase FMS1 / 0.706
2gew FADCholesterol oxidase 1.1.3.6 0.705
2gmj FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.705
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.705
4u2s FDACholesterol oxidase 1.1.3.6 0.705
3we0 FADLysine 2-monooxygenase / 0.704
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.704
1cbo FADCholesterol oxidase 1.1.3.6 0.703
1d7y FADFerredoxin reductase / 0.703
1h83 FADPolyamine oxidase 1.5.3.14 0.703
2q7v FADThioredoxin reductase / 0.703
4tlx FDAKtzI / 0.703
4xbf FADLysine-specific histone demethylase 1A 1 0.703
3lov FADProtoporphyrinogen oxidase / 0.702
2yg5 FADPutrescine oxidase / 0.701
4icy FADPgaE / 0.701
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.701
1kif FADD-amino-acid oxidase 1.4.3.3 0.700
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.700
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.700
1h81 FADPolyamine oxidase 1.5.3.14 0.699
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.698
1nhs FADNADH peroxidase 1.11.1.1 0.698
2q0l FADThioredoxin reductase 1.8.1.9 0.698
3t2z FADSulfide-quinone reductase / 0.698
1tdn FADL-amino-acid oxidase 1.4.3.2 0.697
2iw5 FADLysine-specific histone demethylase 1A 1 0.697
3bi5 FADPolyamine oxidase FMS1 / 0.697
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.696
4yry FADGlutamate synthase, beta subunit / 0.696
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.694
2iid FADL-amino-acid oxidase 1.4.3.2 0.694
3gyj FADCholesterol oxidase 1.1.3.6 0.694
3nlc FADUncharacterized protein / 0.694
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.694
2gr3 FADFerredoxin reductase / 0.693
3uka FADUDP-galactopyranose mutase / 0.693
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.692
1reo FADL-amino-acid oxidase 1.4.3.2 0.691
3cox FADCholesterol oxidase 1.1.3.6 0.691
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.691
1feb FADTrypanothione reductase 1.8.1.12 0.690
2xvf FADPutative flavin-containing monooxygenase / 0.690
3zdn FADMonoamine oxidase N 1.4.3.4 0.690
4b1b FADThioredoxin reductase 1.8.1.9 0.690
4j34 FADKynurenine 3-monooxygenase / 0.690
4tm3 FADKtzI / 0.689
4u2l SFDCholesterol oxidase 1.1.3.6 0.689
2eq7 FADDihydrolipoyl dehydrogenase / 0.688
2bab FADPutative aminooxidase / 0.687
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.687
3cgd FADCoenzyme A disulfide reductase / 0.687
4tlz FADKtzI / 0.687
4u8p FDAUDP-galactopyranose mutase / 0.687
1ges FADGlutathione reductase 1.8.1.7 0.686
1n4u FAECholesterol oxidase 1.1.3.6 0.686
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.686
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.685
5j60 FADThioredoxin reductase / 0.685
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.684
4ynt FDAGlucose oxidase, putative / 0.684
1cc2 FADCholesterol oxidase 1.1.3.6 0.683
1tyt FADTrypanothione reductase 1.8.1.12 0.683
4aos FADSteroid monooxygenase / 0.683
4j36 FADKynurenine 3-monooxygenase / 0.683
1f3p FADFerredoxin reductase / 0.682
3alj FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.682
3f8d FADNADH oxidase/thioredoxin reductase / 0.682
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.682
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.682
5je3 SAHMethyl transferase / 0.682
2xve FADPutative flavin-containing monooxygenase / 0.681
3fmw FADOxygenase / 0.681
3kkj FADRenalase / 0.681
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.680
1nhq FADNADH peroxidase 1.11.1.1 0.680
1pdh FASp-hydroxybenzoate hydroxylase / 0.680
3cn8 FADPolyamine oxidase FMS1 / 0.680
4bk2 FADProbable salicylate monooxygenase / 0.679
2eq6 FADDihydrolipoyl dehydrogenase / 0.678
2wba FADTrypanothione reductase 1.8.1.12 0.678
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.678
4rsl FADFructosyl peptide oxidase / 0.678
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.677
4j33 FADKynurenine 3-monooxygenase / 0.677
4u8j FDAUDP-galactopyranose mutase / 0.677
5i39 FADL-amino acid deaminase / 0.677
4opc FDAConserved Archaeal protein / 0.676
4u8l FDAUDP-galactopyranose mutase / 0.676
1f8w FADNADH peroxidase 1.11.1.1 0.675
2du8 FADD-amino-acid oxidase 1.4.3.3 0.675
2uxx FAJLysine-specific histone demethylase 1A 1 0.675
2zbw FADFerredoxin--NADP reductase / 0.675
4gdc FADUDP-galactopyranose mutase / 0.675
1nhr FADNADH peroxidase 1.11.1.1 0.674
2ba9 FADPutative aminooxidase / 0.674
4g9k FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.674
2eq8 FADDihydrolipoyl dehydrogenase / 0.673
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.673
3t37 FADPyridoxine 4-oxidase / 0.673
3urh FADDihydrolipoyl dehydrogenase / 0.673
4ysh FADGlycine oxidase / 0.673
3ute FADUDP-galactopyranose mutase / 0.672
4yac NAIC alpha-dehydrogenase / 0.671
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.670
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.670
3s5w FADL-ornithine N(5)-monooxygenase / 0.670
4hsu FADLysine-specific histone demethylase 1B 1 0.670
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.669
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.669
4emw FADCoenzyme A disulfide reductase / 0.669
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.669
1gpe FADGlucose oxidase 1.1.3.4 0.668
1nhp FADNADH peroxidase 1.11.1.1 0.668
2bac FADPutative aminooxidase / 0.668
2gsd NADFormate dehydrogenase / 0.668
3ukk FDAUDP-galactopyranose mutase / 0.668
4g74 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.668
4tm0 FADKtzI / 0.668
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.666
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.666
4j2w FADKynurenine 3-monooxygenase / 0.666
4qi5 FADCellobiose dehydrogenase / 0.666
1ogi FADFerredoxin--NADP reductase 1.18.1.2 0.665
2igo FADPyranose 2-oxidase / 0.665
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.665
3cuk FADD-amino-acid oxidase 1.4.3.3 0.665
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.665
4k2x FADPolyketide oxygenase/hydroxylase / 0.665
1n1p FADCholesterol oxidase 1.1.3.6 0.664
3r9u FADThioredoxin reductase / 0.664
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.663
3lsh FADPyranose 2-oxidase / 0.663
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.662
1k0l FADp-hydroxybenzoate hydroxylase / 0.662
3axb FADPutative oxidoreductase / 0.662
3vqr FADPutative oxidoreductase / 0.662
4em4 FADCoenzyme A disulfide reductase / 0.662
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.662
5dbj FADFADH2-dependent halogenase PltA / 0.661
1ger FADGlutathione reductase 1.8.1.7 0.660
2b9y FADPutative aminooxidase / 0.660
2rgh FADAlpha-Glycerophosphate Oxidase / 0.660
2vq7 FADPutative flavin-containing monooxygenase / 0.660
1qo8 FADFumarate reductase flavoprotein subunit / 0.659
1tde FADThioredoxin reductase 1.8.1.9 0.659
2xvh FADPutative flavin-containing monooxygenase / 0.659
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.659
1xpq FADPolyamine oxidase FMS1 / 0.658
1zx9 FADMercuric reductase 1.16.1.1 0.658
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.658
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.658
4bjz FADProbable salicylate monooxygenase / 0.658
4j56 FADThioredoxin reductase 2 1.8.1.9 0.658
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.657
2w0h FADTrypanothione reductase / 0.657
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.657
3alm FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.657
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.657
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.657
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.656
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.656
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.656
4z24 FADPutative GMC-type oxidoreductase R135 1 0.656
1d7l RFLp-hydroxybenzoate hydroxylase / 0.655
1sez FADProtoporphyrinogen oxidase, mitochondrial 1.3.3.4 0.655
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.655
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.655
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.655
4usr FADMonooxygenase / 0.655
3dme FADPutative conserved exported protein / 0.654
3f8p NADNADH oxidase/thioredoxin reductase / 0.654
3b03 VNRIsopentenyl-diphosphate delta-isomerase / 0.653
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.653
4jic FMNGTN Reductase / 0.653
1gal FADGlucose oxidase 1.1.3.4 0.652
1n4v FADCholesterol oxidase 1.1.3.6 0.652
1p1h NADInositol-3-phosphate synthase 5.5.1.4 0.652
3atq FDAConserved Archaeal protein / 0.652
3icr FADCoenzyme A disulfide reductase / 0.652
4nzh FADL-ornithine N(5)-monooxygenase / 0.652
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.651
1b4v FADCholesterol oxidase 1.1.3.6 0.650
1joa FADNADH peroxidase 1.11.1.1 0.650
1mxt FAECholesterol oxidase 1.1.3.6 0.650
1tdo FADL-amino-acid oxidase 1.4.3.2 0.650
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.650
2hv9 SFGmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.650
2jk6 FADTrypanothione reductase / 0.650
4u8n FDAUDP-galactopyranose mutase / 0.650