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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1w2c ANP Inositol-trisphosphate 3-kinase A 2.7.1.127

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 1.000
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.825
4o4d ATPKinase / 0.806
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.740
2pyw ADPMethylthioribose kinase 2.7.1.100 0.733
4o4f ATPKinase / 0.729
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.716
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.715
4o4e ATPKinase / 0.715
2p0a ANPSynapsin-3 / 0.712
3c4w ATPRhodopsin kinase / 0.712
2pzp ACPFibroblast growth factor receptor 2 / 0.709
2if8 ADPInositol polyphosphate multikinase 2.7.1.151 0.708
3rv4 ADPBiotin carboxylase 6.3.4.14 0.708
4c3r ACPAurora kinase A 2.7.11.1 0.706
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.706
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.703
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.703
3bu5 ATPInsulin receptor 2.7.10.1 0.702
2olc ADPMethylthioribose kinase 2.7.1.100 0.701
4gyi ADPUncharacterized protein / 0.700
5bpf ADPD-alanine--D-alanine ligase / 0.696
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.695
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.695
5c1p ADPD-alanine--D-alanine ligase / 0.694
2dwb ANPAurora kinase A 2.7.11.1 0.691
2pz5 ACPFibroblast growth factor receptor 2 / 0.689
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.688
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.688
3hzi ATPSerine/threonine-protein kinase toxin HipA / 0.687
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.685
3c4z ADPRhodopsin kinase / 0.684
5l8l ADPAurora kinase A 2.7.11.1 0.682
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.681
5l8j ADPAurora kinase A 2.7.11.1 0.681
4dee ADPAurora kinase A 2.7.11.1 0.680
5dt4 ATPAurora kinase A 2.7.11.1 0.680
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.678
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.677
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.677
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.677
2pul ACPMethylthioribose kinase 2.7.1.100 0.676
3cly ACPFibroblast growth factor receptor 2 / 0.676
4qny ANPMitogen activated protein kinase, putative / 0.675
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.674
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.674
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.674
4ceg ADPAurora kinase A 2.7.11.1 0.674
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.673
5iqa GNPBifunctional AAC/APH 2.3.1 0.672
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.671
4jrn ANPRhoptry kinase family protein / 0.671
2vqd AP2Biotin carboxylase 6.3.4.14 0.670
2pun ACPMethylthioribose kinase 2.7.1.100 0.669
2py3 ACPFibroblast growth factor receptor 2 / 0.669
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.669
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.668
2pup ADPMethylthioribose kinase 2.7.1.100 0.667
5iqb GNPBifunctional AAC/APH 2.3.1 0.665
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.664
2j9g ADPBiotin carboxylase 6.3.4.14 0.664
4c3p ACPAurora kinase A 2.7.11.1 0.664
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.663
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.663
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.662
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.662
2yaa ATPDeath-associated protein kinase 2 / 0.662
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.662
1m0w ANPGlutathione synthetase 6.3.2.3 0.661
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.661
5iqh GNPBifunctional AAC/APH 2.3.1 0.661
1ztf XYARIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.660
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.660
1ir3 ANPInsulin receptor 2.7.10.1 0.659
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
1cm8 ANPMitogen-activated protein kinase 12 / 0.658
2c2a ADPSensor histidine kinase / 0.658
5dos ATPAurora kinase A 2.7.11.1 0.658
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.657
5dr2 ATPAurora kinase A 2.7.11.1 0.657
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.656
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.656
5l8k ADPAurora kinase A 2.7.11.1 0.656
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.655
3orp AGSSerine/threonine protein kinase / 0.655
5byl GCPBifunctional AAC/APH 2.3.1 0.655
5c1o ANPD-alanine--D-alanine ligase / 0.655
5iqi GNPBifunctional AAC/APH 2.3.1 0.655
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.654
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.654
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.653
3t8o ATPRhodopsin kinase / 0.653
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.653
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.652
1ol6 ATPAurora kinase A 2.7.11.1 0.651
3wo1 ADPAlanine--anticapsin ligase / 0.651
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.650
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.650
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.650
5a7y SAHtRNA (adenine(9)-N1)-methyltransferase 2.1.1.218 0.650
5eg3 ACPFibroblast growth factor receptor 2 / 0.650