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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1w06 W05 Isopenicillin N synthase 1.21.3.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1w06 W05Isopenicillin N synthase 1.21.3.1 0.985
2wo7 ASVIsopenicillin N synthase 1.21.3.1 0.949
2y60 M8FIsopenicillin N synthase 1.21.3.1 0.947
1hb3 SCVIsopenicillin N synthase 1.21.3.1 0.933
1obn ASVIsopenicillin N synthase 1.21.3.1 0.924
1qiq ACCIsopenicillin N synthase 1.21.3.1 0.921
1hb1 OCVIsopenicillin N synthase 1.21.3.1 0.904
2ivi ACWIsopenicillin N synthase 1.21.3.1 0.891
3zoi M2WIsopenicillin N synthase 1.21.3.1 0.875
1bk0 ACVIsopenicillin N synthase 1.21.3.1 0.874
1uzw CDHIsopenicillin N synthase 1.21.3.1 0.862
1oc1 ASVIsopenicillin N synthase 1.21.3.1 0.857
1blz ACVIsopenicillin N synthase 1.21.3.1 0.845
2vbp VB1Isopenicillin N synthase 1.21.3.1 0.844
1qjf ACSIsopenicillin N synthase 1.21.3.1 0.836
2bu9 HFVIsopenicillin N synthase 1.21.3.1 0.835
1odn APVIsopenicillin N synthase 1.21.3.1 0.802
2vbd V10Isopenicillin N synthase 1.21.3.1 0.801
2jb4 A14Isopenicillin N synthase 1.21.3.1 0.797
2y6f M9FIsopenicillin N synthase 1.21.3.1 0.782
2vcm M11Isopenicillin N synthase 1.21.3.1 0.756
2bjs ACVIsopenicillin N synthase 1.21.3.1 0.747
1df7 MTXDihydrofolate reductase 1.5.1.3 0.666
4bqs K2QShikimate kinase 2.7.1.71 0.666
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.666
3lnc 5GPGuanylate kinase / 0.664
3zky WT4Isopenicillin N synthase 1.21.3.1 0.664
4bb3 KKAIsopenicillin N synthase 1.21.3.1 0.664
1ex7 5GPGuanylate kinase 2.7.4.8 0.660
3uwq U5POrotidine 5'-phosphate decarboxylase / 0.659
1arg PPDAspartate aminotransferase 2.6.1.1 0.658
5bp9 SAHPutative methyltransferase protein / 0.658
5ccc DDFDihydrofolate reductase 1.5.1.3 0.656
1dhf FOLDihydrofolate reductase 1.5.1.3 0.653
3rt8 CWDGlutamate receptor 3 / 0.653
4i1n FOLDihydrofolate reductase 1.5.1.3 0.652
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.651