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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1vrw NAI Enoyl-ACP reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1vrw NAIEnoyl-ACP reductase / 1.161
1v35 NAIEnoyl-ACP reductase / 0.919
2nq8 ZIDEnoyl-ACP reductase / 0.892
5koi NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.876
4o1m NADEnoyl-acyl carrier reductase / 0.857
4m87 NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.824
4oxy NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.818
3uic NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.811
2aqk NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.799
2wyv NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.798
2nv6 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.782
4zju NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.780
4dti NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.776
2aqh NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.771
2aqi NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.768
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.765
4dqu NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.761
2aq8 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.754
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.746
4eue NAITrans-2-enoyl-CoA reductase [NADH] / 0.746
4yag NAIC alpha-dehydrogenase / 0.743
1eny NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.740
3zu2 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.740
3r3s NADPutative oxidoreductase / 0.738
2yw9 NAPEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.731
4trn NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.730
4bii NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.729
3ijr NADOxidoreductase, short chain dehydrogenase/reductase family / 0.725
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.724
5jyd NADShort chain dehydrogenase / 0.724
2gdz NAD15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.1.1.141 0.718
2h9i EADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.713
4dre NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.711
1xg5 NAPDehydrogenase/reductase SDR family member 11 / 0.709
3rj9 NADAlcohol dehydrogenase 1.1.1.1 0.709
4yai NAIC alpha-dehydrogenase / 0.705
3gy0 NAPNAD(P)-dependent oxidoreductase / 0.702
3oew NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.701
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.700
3p19 NDPPutative blue fluorescent protein / 0.696
4kwh NAPReductase homolog / 0.694
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.692
2ztu NADD(-)-3-hydroxybutyrate dehydrogenase / 0.689
4bqp NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.688
2pr2 DG1Enoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.687
1eno NADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic 1.3.1.9 0.686
3oey NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.686
3tox NAPPutative oxidoreductase / 0.686
3of2 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.684
3pgx NADUncharacterized NAD-dependent oxidoreductase MAP_4146 / 0.684
2jah NDPClavaldehyde dehydrogenase / 0.682
4k6f NAPPutative Acetoacetyl-CoA reductase / 0.679
3w8d NAD3-hydroxybutyrate dehydrogenase / 0.678
5jy1 NADPutative short-chain dehydrogenase/reductase / 0.678
1x7h NDPPutative ketoacyl reductase 1.3.1 0.677
4b79 NADProbable short-chain dehydrogenase / 0.677
4hbg NDP3-oxoacyl-[acyl-carrier-protein] reductase 1.1.1.100 0.677
1pr9 NAPL-xylulose reductase 1.1.1.10 0.676
1cyd NDPCarbonyl reductase [NADPH] 2 1.1.1.184 0.675
2b37 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.673
1bdb NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase / 0.669
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.669
4rf2 NAPNADPH dependent R-specific alcohol dehydrogenase / 0.669
3tsc NADUncharacterized protein / 0.668
2ntj P1HEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.667
3bhi NAPCarbonyl reductase [NADPH] 1 1.1.1.184 0.666
1xkq NDPUncharacterized protein / 0.665
4bmv NAPShort-chain dehydrogenase / 0.664
4j7x NAPSepiapterin reductase 1.1.1.153 0.664
3ai3 NDPNADPH-sorbose reductase / 0.663
4is3 NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 1.17.98.1 0.663
4wec NADShort chain dehydrogenase / 0.663
4i9b NADPutative betaine aldehyde dehyrogenase / 0.662
4iqg NAPShort-chain dehydrogenase/reductase SDR / 0.662
1p44 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.660
3aut NAIGlucose 1-dehydrogenase 4 1.1.1.47 0.660
3sx2 NADUncharacterized protein / 0.660
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.659
1sny NAPLD36273p / 0.658
2q2v NADBeta-D-hydroxybutyrate dehydrogenase / 0.658
1b2l NDCAlcohol dehydrogenase 1.1.1.1 0.657
1rwb NADGlucose 1-dehydrogenase 1.1.1.47 0.657
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.657
3l77 NJPShort-chain alcohol dehydrogenase / 0.657
1vl8 NAPOxidoreductase, short chain dehydrogenase/reductase family / 0.655
2rbe NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.655
5idw NAPShort-chain dehydrogenase/reductase SDR / 0.655
1u7t TDT3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.654
5cpb NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.654
2ztv NADD(-)-3-hydroxybutyrate dehydrogenase / 0.653
4c7k NAPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.653
3geg NADShort-chain dehydrogenase/reductase SDR / 0.651
3wds NADNADH-dependent quinuclidinone reductase / 0.651
1e3w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.650
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.650
2zat NAPDehydrogenase/reductase SDR family member 4 1.1.1.184 0.650