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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1uxv NAP NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.227
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.216
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.201
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.153
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.064
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.049
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.920
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.840
4i8p NADAminoaldehyde dehydrogenase 1 / 0.822
3b4w NADAldehyde dehydrogenase family protein / 0.807
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.803
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.795
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.794
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.793
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.790
4pz2 NADAldehyde dehydrogenase 2-6 / 0.788
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.779
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.769
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.765
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.760
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.756
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.755
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.753
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.748
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.748
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.747
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.746
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.746
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.741
3haz NADBifunctional protein PutA / 0.741
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.733
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.732
2jg7 NADAntiquitin / 0.731
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.718
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.708
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.707
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.703
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.702
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.701
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.701
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.700
4nmk NAPAldehyde dehydrogenase / 0.700
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.698
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.697
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.697
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.696
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.695
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.694
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.693
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.691
4i8q NADPutative betaine aldehyde dehyrogenase / 0.689
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.688
3iwj NADAminoaldehyde dehydrogenase / 0.687
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.682
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.679
4i3v NADAldehyde dehydrogenase (NAD+) / 0.679
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.674
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.671
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.669
2ilu NDPLactaldehyde dehydrogenase 1.2.1.22 0.668
4pxl NADAldehyde dehydrogenase3 / 0.667
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.662
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.661
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.660
5dib NADBetaine-aldehyde dehydrogenase / 0.658
4i3w NADAldehyde dehydrogenase (NAD+) / 0.654
1ez0 NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.653
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.653
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.652