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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1uxp NAP NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.330
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.312
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.216
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.193
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.116
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.101
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.960
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.889
4i8p NADAminoaldehyde dehydrogenase 1 / 0.830
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.826
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.821
4pz2 NADAldehyde dehydrogenase 2-6 / 0.817
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.815
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.806
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.797
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.793
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.792
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.791
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.790
3b4w NADAldehyde dehydrogenase family protein / 0.786
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.785
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.777
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.767
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.766
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.765
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.761
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.760
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.759
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.759
2jg7 NADAntiquitin / 0.756
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.751
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.750
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.748
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.746
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.744
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.733
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.729
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.724
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.723
4i8q NADPutative betaine aldehyde dehyrogenase / 0.719
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.712
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.711
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.710
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.708
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.707
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.695
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.693
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.690
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.688
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.688
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.685
3haz NADBifunctional protein PutA / 0.684
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.682
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.681
4pxl NADAldehyde dehydrogenase3 / 0.678
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.678
4c3s NADAldehyde Dehydrogenase / 0.677
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 0.676
4i3v NADAldehyde dehydrogenase (NAD+) / 0.669
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.668
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.668
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.667
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.662
2wme NAPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.662
4pt0 NADAldehyde dehydrogenase / 0.662
1bi9 NADRetinal dehydrogenase 2 / 0.661
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.656
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.655
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.654
4i3w NADAldehyde dehydrogenase (NAD+) / 0.653
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.651
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.651
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.651