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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1uv5 BRW Glycogen synthase kinase-3 beta 2.7.11.26

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1uv5 BRWGlycogen synthase kinase-3 beta 2.7.11.26 0.990
1q41 IXMGlycogen synthase kinase-3 beta 2.7.11.26 0.851
3say OFTGlycogen synthase kinase-3 beta 2.7.11.26 0.762
4fkp LS5Cyclin-dependent kinase 2 2.7.11.22 0.749
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.713
3py0 SU9Cyclin-dependent kinase 2 2.7.11.22 0.707
3r8p Z46Cyclin-dependent kinase 2 2.7.11.22 0.703
4fkw 62KCyclin-dependent kinase 2 2.7.11.22 0.702
3eb0 DRKUncharacterized protein / 0.688
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.687
2c3k ABOSerine/threonine-protein kinase Chk1 2.7.11.1 0.682
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.680
1unh IXMCyclin-dependent-like kinase 5 2.7.11.1 0.677
4fx3 60KCyclin-dependent kinase 2 2.7.11.22 0.676
3hzt J60Calmodulin-like domain protein kinase isoform 3 / 0.674
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.671
3qql X03Cyclin-dependent kinase 2 2.7.11.22 0.669
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.668
1ke7 LS3Cyclin-dependent kinase 2 2.7.11.22 0.664
4fki 09KCyclin-dependent kinase 2 2.7.11.22 0.662
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.660
3dcv 55ESerine/threonine-protein kinase pim-1 2.7.11.1 0.659
3pj8 404Cyclin-dependent kinase 2 2.7.11.22 0.656
1gih 1PUCyclin-dependent kinase 2 2.7.11.22 0.655
2hxq 373Serine/threonine-protein kinase Chk1 2.7.11.1 0.652
3l9n L9NcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4ek6 10KCyclin-dependent kinase 2 2.7.11.22 0.651
4fsu HK5Serine/threonine-protein kinase Chk1 2.7.11.1 0.650