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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1uu3 LY4 3-phosphoinositide-dependent protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1uu3 LY43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.957
1uu7 BI23-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.814
1uvr BI83-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.801
1uu9 BI33-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.787
3orz BI43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.761
1uu8 BI13-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.760
3otu BI43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.742
2vd5 BI8Myotonin-protein kinase 2.7.11.1 0.700
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.684
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.680
2jed LG8Protein kinase C theta type 2.7.11.13 0.679
2bik BI1Serine/threonine-protein kinase pim-1 2.7.11.1 0.659
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.658
3a60 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.658
4oth DRNSerine/threonine-protein kinase N1 / 0.654
1zrz BI1Protein kinase C iota type 2.7.11.13 0.651
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.650