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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1us0 LDT Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1us0 LDTAldose reductase 1.1.1.21 1.141
2i16 LDTAldose reductase 1.1.1.21 1.140
2i17 LDTAldose reductase 1.1.1.21 1.122
3ghr LDTAldose reductase 1.1.1.21 1.105
3ghs LDTAldose reductase 1.1.1.21 1.101
2qxw LDTAldose reductase 1.1.1.21 1.100
3lbo LDTAldose reductase 1.1.1.21 1.060
3ght LDTAldose reductase 1.1.1.21 1.047
3ghu LDTAldose reductase 1.1.1.21 1.046
3lz5 LDTAldose reductase 1.1.1.21 1.042
3ld5 LDTAldose reductase 1.1.1.21 1.035
3lql LDTAldose reductase 1.1.1.21 1.022
3m4h 388Aldose reductase 1.1.1.21 0.959
2iki 388Aldose reductase 1.1.1.21 0.942
2ikj 393Aldose reductase 1.1.1.21 0.851
1iei ZESAldose reductase 1.1.1.21 0.813
2pdj 393Aldose reductase 1.1.1.21 0.806
2pdc 393Aldose reductase 1.1.1.21 0.800
2pzn 393Aldose reductase 1.1.1.21 0.797
3t42 3T4Aldose reductase 1.1.1.21 0.797
3m64 393Aldose reductase 1.1.1.21 0.793
2pdp 393Aldose reductase 1.1.1.21 0.767
3mc5 393Aldose reductase 1.1.1.21 0.759
2fz8 ZSTAldose reductase 1.1.1.21 0.741
1t40 ID5Aldose reductase 1.1.1.21 0.729
2pdu 393Aldose reductase 1.1.1.21 0.729
2hvn ZSTAldose reductase 1.1.1.21 0.728
2pdi ZSTAldose reductase 1.1.1.21 0.726
2pdq 47DAldose reductase 1.1.1.21 0.700
3m0i ZSTAldose reductase 1.1.1.21 0.700
2inz OHPAldose reductase 1.1.1.21 0.691
3s3g TLTAldose reductase 1.1.1.21 0.681
2fzd TOLAldose reductase 1.1.1.21 0.678
2pdl TOLAldose reductase 1.1.1.21 0.674
1frb ZSTAldose reductase-related protein 2 / 0.673
2ikh LITAldose reductase 1.1.1.21 0.673
2nvc ITAAldose reductase 1.1.1.21 0.672
2iqd LPAAldose reductase 1.1.1.21 0.667
1pwl BFIAldose reductase 1.1.1.21 0.659
2dv0 ZSTAldose reductase 1.1.1.21 0.659
2ipw 2CLAldose reductase 1.1.1.21 0.655
4yu1 53NAldose reductase 1.1.1.21 0.652
2pdh 47DAldose reductase 1.1.1.21 0.651
2pdx ZSTAldose reductase 1.1.1.21 0.650