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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1urw I1P Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1urw I1PCyclin-dependent kinase 2 2.7.11.22 0.912
2w06 FRVCyclin-dependent kinase 2 2.7.11.22 0.771
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.768
1oit HDTCyclin-dependent kinase 2 2.7.11.22 0.750
3r9o Z71Cyclin-dependent kinase 2 2.7.11.22 0.739
3r9d X6BCyclin-dependent kinase 2 2.7.11.22 0.733
3sw4 18KCyclin-dependent kinase 2 2.7.11.22 0.721
4fko 20KCyclin-dependent kinase 2 2.7.11.22 0.714
3rpy 27ZCyclin-dependent kinase 2 2.7.11.22 0.711
3unj 0BXCyclin-dependent kinase 2 2.7.11.22 0.709
1y8y CT7Cyclin-dependent kinase 2 2.7.11.22 0.706
3sw7 19KCyclin-dependent kinase 2 2.7.11.22 0.705
1pxm CK5Cyclin-dependent kinase 2 2.7.11.22 0.703
2hzi JINTyrosine-protein kinase ABL1 2.7.10.2 0.700
3qtu X44Cyclin-dependent kinase 2 2.7.11.22 0.699
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.696
4aot GW8Serine/threonine-protein kinase 10 2.7.11.1 0.695
1pxp CK8Cyclin-dependent kinase 2 2.7.11.22 0.692
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.690
4ek8 16KCyclin-dependent kinase 2 2.7.11.22 0.681
2c5n CK8Cyclin-dependent kinase 2 2.7.11.22 0.675
1pxl CK4Cyclin-dependent kinase 2 2.7.11.22 0.672
3cjg KIMVascular endothelial growth factor receptor 2 2.7.10.1 0.672
2uzo C62Cyclin-dependent kinase 2 2.7.11.22 0.670
2iw8 4SPCyclin-dependent kinase 2 2.7.11.22 0.668
4eok 4SPCyclin-dependent kinase 2 2.7.11.22 0.668
4fkp LS5Cyclin-dependent kinase 2 2.7.11.22 0.666
2jkk BI9Focal adhesion kinase 1 2.7.10.2 0.665
2vv9 IM9Cyclin-dependent kinase 2 2.7.11.22 0.665
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 0.663
2p33 J07Mitogen-activated protein kinase 10 2.7.11.24 0.662
2c5y MTWCyclin-dependent kinase 2 2.7.11.22 0.661
2np8 CC3Aurora kinase A 2.7.11.1 0.661
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 0.661
4bcq TJFCyclin-dependent kinase 2 2.7.11.22 0.659
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.658
2w05 FRTCyclin-dependent kinase 2 2.7.11.22 0.657
4ez3 0S0Cyclin-dependent kinase 2 2.7.11.22 0.657
2c6m DT5Cyclin-dependent kinase 2 2.7.11.22 0.653
2z7l S91Mitogen-activated protein kinase 1 2.7.11.24 0.652
4c3f 7KWTyrosine-protein kinase Lck 2.7.10.2 0.652
4dea NHIAurora kinase A 2.7.11.1 0.652
1m52 P17Tyrosine-protein kinase ABL1 2.7.10.2 0.651
2c6o 4SPCyclin-dependent kinase 2 2.7.11.22 0.651
2j9m PY8Cyclin-dependent kinase 2 2.7.11.22 0.651
1y57 MPZProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.650