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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1u72 MTX Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1u72 MTXDihydrofolate reductase 1.5.1.3 1.087
1u70 MTXDihydrofolate reductase 1.5.1.3 0.862
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.845
1dre MTXDihydrofolate reductase 1.5.1.3 0.843
3eig MTXDihydrofolate reductase 1.5.1.3 0.840
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.831
4qi9 MTXDihydrofolate reductase / 0.827
1hfq MOTDihydrofolate reductase 1.5.1.3 0.825
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.810
3drc MTXDihydrofolate reductase 1.5.1.3 0.801
1ohj COPDihydrofolate reductase 1.5.1.3 0.799
3dau MTXDihydrofolate reductase 1.5.1.3 0.799
4dfr MTXDihydrofolate reductase 1.5.1.3 0.793
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.790
4p66 MTXDihydrofolate reductase / 0.786
1dls MTXDihydrofolate reductase 1.5.1.3 0.779
4m6k FOLDihydrofolate reductase 1.5.1.3 0.778
1dhi MTXDihydrofolate reductase 1.5.1.3 0.774
3ia4 MTXDihydrofolate reductase / 0.768
1hfr MOTDihydrofolate reductase 1.5.1.3 0.767
5hi6 MTXDihydrofolate reductase / 0.767
3tq9 MTXDihydrofolate reductase / 0.759
2drc MTXDihydrofolate reductase 1.5.1.3 0.758
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.756
2qk8 MTXDihydrofolate reductase / 0.754
3och 2MXDihydrofolate reductase 1.5.1.3 0.754
7dfr FOLDihydrofolate reductase 1.5.1.3 0.753
3tqb FOLDihydrofolate reductase / 0.749
1df7 MTXDihydrofolate reductase 1.5.1.3 0.747
1hfp MOTDihydrofolate reductase 1.5.1.3 0.747
4x5g FOLDihydrofolate reductase 1.5.1.3 0.747
1drb MTXDihydrofolate reductase 1.5.1.3 0.746
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.746
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.744
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.743
3dfr MTXDihydrofolate reductase 1.5.1.3 0.741
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.738
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.737
3frd DHFDihydrofolate reductase 1.5.1.3 0.735
3ghw GHWDihydrofolate reductase 1.5.1.3 0.731
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.730
1dra MTXDihydrofolate reductase 1.5.1.3 0.728
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.724
1drf FOLDihydrofolate reductase 1.5.1.3 0.723
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.722
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.722
1ohk COPDihydrofolate reductase 1.5.1.3 0.721
4keb FOLDihydrofolate reductase 1.5.1.3 0.721
4kfj FOLDihydrofolate reductase 1.5.1.3 0.718
4x5h FOLDihydrofolate reductase 1.5.1.3 0.718
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.717
4p68 MTXDihydrofolate reductase / 0.717
1tdr MTXDihydrofolate reductase 1.5.1.3 0.716
4i13 FOLDihydrofolate reductase 1.5.1.3 0.715
2w3m FOLDihydrofolate reductase 1.5.1.3 0.714
4i1n FOLDihydrofolate reductase 1.5.1.3 0.714
1jom FFODihydrofolate reductase 1.5.1.3 0.713
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.712
1dds MTXDihydrofolate reductase 1.5.1.3 0.708
1dyh DZFDihydrofolate reductase 1.5.1.3 0.708
1dhf FOLDihydrofolate reductase 1.5.1.3 0.707
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.707
4kjj FOLDihydrofolate reductase 1.5.1.3 0.704
1e26 GPBDihydrofolate reductase 1.5.1.3 0.703
1dyi FOLDihydrofolate reductase 1.5.1.3 0.700
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.697
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.696
4x5i FOLDihydrofolate reductase 1.5.1.3 0.695
2zza FOLDihydrofolate reductase / 0.693
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.693
1dyj DDFDihydrofolate reductase 1.5.1.3 0.692
1jol FFODihydrofolate reductase 1.5.1.3 0.689
5ccc DDFDihydrofolate reductase 1.5.1.3 0.689
1re7 FOLDihydrofolate reductase 1.5.1.3 0.675
4m6l 21VDihydrofolate reductase 1.5.1.3 0.673
4fhb FOLDihydrofolate reductase 1.5.1.3 0.670
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.668
1ddr MTXDihydrofolate reductase 1.5.1.3 0.667
3dat MTXDihydrofolate reductase / 0.665
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.664
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.663
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.662
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.661
4e5i 0N9Polymerase acidic protein / 0.660
4eil FOLBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.659
4x5f FOLDihydrofolate reductase 1.5.1.3 0.659
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.656
1dhj MTXDihydrofolate reductase 1.5.1.3 0.654
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.654
3kjs DQ1Bifunctional dihydrofolate reductase-thymidylate synthase / 0.653