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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1u70 MTX Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1u70 MTXDihydrofolate reductase 1.5.1.3 1.030
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.888
1dls MTXDihydrofolate reductase 1.5.1.3 0.882
3eig MTXDihydrofolate reductase 1.5.1.3 0.863
1u72 MTXDihydrofolate reductase 1.5.1.3 0.862
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.859
4dfr MTXDihydrofolate reductase 1.5.1.3 0.857
3ia4 MTXDihydrofolate reductase / 0.838
4qi9 MTXDihydrofolate reductase / 0.834
1dhi MTXDihydrofolate reductase 1.5.1.3 0.832
4p66 MTXDihydrofolate reductase / 0.823
1drb MTXDihydrofolate reductase 1.5.1.3 0.819
1dra MTXDihydrofolate reductase 1.5.1.3 0.816
1df7 MTXDihydrofolate reductase 1.5.1.3 0.814
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.813
3drc MTXDihydrofolate reductase 1.5.1.3 0.813
2qk8 MTXDihydrofolate reductase / 0.812
1hfq MOTDihydrofolate reductase 1.5.1.3 0.809
3och 2MXDihydrofolate reductase 1.5.1.3 0.808
3dau MTXDihydrofolate reductase 1.5.1.3 0.807
1dhj MTXDihydrofolate reductase 1.5.1.3 0.806
2drc MTXDihydrofolate reductase 1.5.1.3 0.799
5hi6 MTXDihydrofolate reductase / 0.799
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.796
4m6k FOLDihydrofolate reductase 1.5.1.3 0.795
3dfr MTXDihydrofolate reductase 1.5.1.3 0.793
1ohj COPDihydrofolate reductase 1.5.1.3 0.789
3tq9 MTXDihydrofolate reductase / 0.784
1hfr MOTDihydrofolate reductase 1.5.1.3 0.783
1dre MTXDihydrofolate reductase 1.5.1.3 0.776
1hfp MOTDihydrofolate reductase 1.5.1.3 0.774
1e26 GPBDihydrofolate reductase 1.5.1.3 0.767
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.765
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.763
1tdr MTXDihydrofolate reductase 1.5.1.3 0.762
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.759
4p68 MTXDihydrofolate reductase / 0.758
3td8 D2RDihydrofolate reductase 1.5.1.3 0.755
1ddr MTXDihydrofolate reductase 1.5.1.3 0.751
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.749
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.749
1dyi FOLDihydrofolate reductase 1.5.1.3 0.748
4keb FOLDihydrofolate reductase 1.5.1.3 0.745
2w3m FOLDihydrofolate reductase 1.5.1.3 0.737
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.737
3dat MTXDihydrofolate reductase / 0.732
2zza FOLDihydrofolate reductase / 0.731
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.731
1dyh DZFDihydrofolate reductase 1.5.1.3 0.730
4x5f FOLDihydrofolate reductase 1.5.1.3 0.729
4x5h FOLDihydrofolate reductase 1.5.1.3 0.727
4i13 FOLDihydrofolate reductase 1.5.1.3 0.723
4m6l 21VDihydrofolate reductase 1.5.1.3 0.721
1dds MTXDihydrofolate reductase 1.5.1.3 0.720
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.719
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.718
4kfj FOLDihydrofolate reductase 1.5.1.3 0.717
3ghw GHWDihydrofolate reductase 1.5.1.3 0.716
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.716
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.715
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.712
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.711
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.708
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.704
1drf FOLDihydrofolate reductase 1.5.1.3 0.703
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.700
4x5g FOLDihydrofolate reductase 1.5.1.3 0.699
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.695
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.694
4i1n FOLDihydrofolate reductase 1.5.1.3 0.691
1jom FFODihydrofolate reductase 1.5.1.3 0.689
3tqb FOLDihydrofolate reductase / 0.689
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.689
1re7 FOLDihydrofolate reductase 1.5.1.3 0.688
7dfr FOLDihydrofolate reductase 1.5.1.3 0.688
1ohk COPDihydrofolate reductase 1.5.1.3 0.687
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.684
4kjj FOLDihydrofolate reductase 1.5.1.3 0.681
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.680
1klk PMDDihydrofolate reductase 1.5.1.3 0.677
4ixg IXGDihydrofolate reductase 1.5.1.3 0.675
2d0k FOLDihydrofolate reductase 1.5.1.3 0.674
4h95 06UDihydrofolate reductase 1.5.1.3 0.671
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.670
1jol FFODihydrofolate reductase 1.5.1.3 0.669
1daj MOTDihydrofolate reductase 1.5.1.3 0.668
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.668
1dyj DDFDihydrofolate reductase 1.5.1.3 0.667
1ao8 MTXDihydrofolate reductase 1.5.1.3 0.665
3inv C50Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.665
1dhf FOLDihydrofolate reductase 1.5.1.3 0.663
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.662
4kd7 9DRDihydrofolate reductase 1.5.1.3 0.662
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.661
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.661
2a84 ATPPantothenate synthetase 6.3.2.1 0.657
2fzj DH3Dihydrofolate reductase 1.5.1.3 0.655
3gyf 51PDihydrofolate reductase 1.5.1.3 0.655
2dhf DZFDihydrofolate reductase 1.5.1.3 0.654
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.653
4fhb FOLDihydrofolate reductase 1.5.1.3 0.653
1aoe GW3Dihydrofolate reductase 1.5.1.3 0.651
3ghv GHCDihydrofolate reductase 1.5.1.3 0.650
4x5i FOLDihydrofolate reductase 1.5.1.3 0.650
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.650