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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1u5r ATP Serine/threonine-protein kinase TAO2 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.933
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.773
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.752
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.746
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.744
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.742
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.740
4bn1 ADPAurora kinase A 2.7.11.1 0.740
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.740
4xlv ACPInsulin receptor 2.7.10.1 0.740
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.738
4dee ADPAurora kinase A 2.7.11.1 0.737
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.734
4qny ANPMitogen activated protein kinase, putative / 0.731
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.729
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.729
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.728
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.724
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.724
5dt3 ATPAurora kinase A 2.7.11.1 0.723
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.722
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.721
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.720
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.719
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.718
4o1p ANPRibonuclease L / 0.718
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.717
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.715
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.714
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.713
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.713
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.711
5dr2 ATPAurora kinase A 2.7.11.1 0.711
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.710
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.710
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.708
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.706
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.705
4ceg ADPAurora kinase A 2.7.11.1 0.704
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.702
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.700
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.698
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.697
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.697
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.696
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.695
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.695
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.695
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.695
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.693
2olc ADPMethylthioribose kinase 2.7.1.100 0.691
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.690
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.690
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.689
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.688
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.688
1cm8 ANPMitogen-activated protein kinase 12 / 0.687
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.687
2pun ACPMethylthioribose kinase 2.7.1.100 0.687
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.686
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.685
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.685
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.684
1m0w ANPGlutathione synthetase 6.3.2.3 0.683
5eg3 ACPFibroblast growth factor receptor 2 / 0.683
1ol6 ATPAurora kinase A 2.7.11.1 0.681
2zdg ADPD-alanine--D-alanine ligase / 0.681
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.680
2yaa ATPDeath-associated protein kinase 2 / 0.680
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.679
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.678
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.678
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.678
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.678
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.677
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.677
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.677
2pui ADPMethylthioribose kinase 2.7.1.100 0.676
2pml ANPUncharacterized protein / 0.675
2pyw ADPMethylthioribose kinase 2.7.1.100 0.674
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.674
3q5i ANPProtein kinase, putative / 0.674
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.674
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.673
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.673
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.673
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.672
1ol7 ADPAurora kinase A 2.7.11.1 0.672
2pup ADPMethylthioribose kinase 2.7.1.100 0.672
3c4z ADPRhodopsin kinase / 0.672
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.672
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
2itn ANPEpidermal growth factor receptor 2.7.10.1 0.670
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.670
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.668
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.667
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.666
5dos ATPAurora kinase A 2.7.11.1 0.666
2dwb ANPAurora kinase A 2.7.11.1 0.665
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
2pz5 ACPFibroblast growth factor receptor 2 / 0.663
2uvy GVIcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.663
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.662
4o4f ATPKinase / 0.662
4q5h ANPProtein kinase OspG 2.7 0.662
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.661
2py3 ACPFibroblast growth factor receptor 2 / 0.661
2uw0 GVKcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4o4e ATPKinase / 0.661
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.660
4o4d ATPKinase / 0.660
1mq4 ADPAurora kinase A 2.7.11.1 0.659
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.659
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.658
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
1ol5 ADPAurora kinase A 2.7.11.1 0.657
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.657
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.657
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.657
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.656
2pul ACPMethylthioribose kinase 2.7.1.100 0.656
1e8x ATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2.7.1.153 0.655
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.655
5dn3 ATPAurora kinase A 2.7.11.1 0.655
3t8o ATPRhodopsin kinase / 0.653
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.653
1h1r 6CPCyclin-dependent kinase 2 2.7.11.22 0.652
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.652
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.652
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.651
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.651
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
5ce3 ADPProtein kinase YopO / 0.650