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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1u59 STU Tyrosine-protein kinase ZAP-70 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 1.141
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 1.010
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.946
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.939
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.905
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.889
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.888
3a62 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.865
1xjd STUProtein kinase C theta type 2.7.11.13 0.859
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.843
1stc STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.828
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.813
4yzc STUSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.812
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.807
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.802
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.801
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.799
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.797
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.776
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.775
4qmy STUSerine/threonine-protein kinase 24 2.7.11.1 0.773
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.772
1nvs UCMSerine/threonine-protein kinase Chk1 2.7.11.1 0.761
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.747
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.734
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.725
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.723
3f69 XDRSerine/threonine-protein kinase PknB 2.7.11.1 0.723
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.719
3a60 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.700
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.696
1x8b 824Wee1-like protein kinase 2.7.10.2 0.687
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.683
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.682
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.679
1wvx BD4Death-associated protein kinase 1 2.7.11.1 0.676
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.667
3bi6 396Wee1-like protein kinase 2.7.10.2 0.663
4e5f 0N7Polymerase acidic protein / 0.660
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.659
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.655
4bib IEOMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.654
1q3d STUGlycogen synthase kinase-3 beta 2.7.11.26 0.653
3cr0 809Wee1-like protein kinase 2.7.10.2 0.652
3zew STUEphrin type-B receptor 4 2.7.10.1 0.651
1byg STUTyrosine-protein kinase CSK / 0.650